By Gavin van Marle 10/04/2015 A new type of training initiative for the container shipping line industry has broadened its reach with the appointment of new sales agents in France and Singapore.LinerGame was developed last year by former Maersk executive and SeaIntel founder Lars Jensen, along with shipping academics Nicolas Guilbert and Niels Rytter, and is “a table-top simulation game using container vessels made from LEGO bricks” that trains industry newcomers “as well as advanced simulation of shipping processes for experienced liner executives”.Chalmers University in Gothenburg recently adopted it as part of its curriculum in Shipping and Marine Technology, and the company is in discussion to see it adopted in other educational establishments.As part of that expansion it has appointed Charles Moret in France and Singapore-based, and some time Loadstar contributor, Andy Lane.“The expansion will allow LinerGame to more easily establish local training and teambuilding sessions for both small and large shipping companies outside of Denmark, and we are planning to establish additional agencies going forward,” Mr Jensen said.
Turning off the function of a single protein-coding gene — called USF1 — could offer insight into how to treat a handful of cardiometabolic diseases like obesity, diabetes, and atherosclerosis. Lessening the gene’s expression activates calorie-burning brown fat, keeping mice lean even when they’re fed a high-fat diet. Here’s what lead researcher Dr. Pirkka-Pekka Laurila of the University of Helsinki said about the findings, published in the new Science Translational Medicine.What happens when you block USF1’s expression?When USF1 expression is blocked in mice, the mice are protected against weight gain, even when fed a high-fat diet. In humans, individuals who had a lesser amount of USF1 gene product improved their lipid levels, were more insulin sensitive, and developed fewer plaques in the arteries.How did that impact fat in the body?When USF1 was inactivated in the mice, the brown adipose [fat] tissue became more active in burning fats and lipids. It cleared sugar and triglycerides more rapidly from the circulation, improving blood lipid levels.advertisement About the Author Reprints By Megan Thielking Jan. 28, 2016 Reprints News Editor What’s the potential usefulness of that finding?These findings suggest that USF1 could be a therapeutic target for cardiovascular and metabolic disease. Genes have evolved to serve well-defined functions in our bodies. How can loss of USF1 be beneficial for metabolism? In the Paleolithic period, with a cycle of famine and feast, USF1 might have been an important player in storing energy. In the current world, with constant feast, the energy-storing function of USF1 might be redundant.For more Lab Chats, subscribe to the free Morning Rounds newsletter. [email protected] @meggophone Tags geneticsmedical researchweight gain A heavy set man rests on a bench. Rogelio V. Solis/AP Lab ChatHow turning off a single gene could help block weight gain Megan Thielking
HealthTheir genes put them at high risk of Alzheimer’s. So they’re experimenting — on themselves “It gets overwhelming, in terms of, ‘What the heck do I do?’” said Theresa, an APOE4 carrier who did not want her full name used to protect her privacy. “That’s one of the benefits of this APOE4 group: We discuss all these things, and try and clarify them to make sense of it all.” About the Author Reprints One approach that’s circulated heavily in the community is the low-carb, high-fat “ketogenic diet.” Much like the popular Atkins diet, it’s meant to retrain the body to use fat, rather than glucose, as its primary source of fuel. Ketogenic diets first proved useful in the 1920s to prevent seizures in some patients with epilepsy — hinting that the diet may have a broader neuroprotective effect. The diet has not been shown to improve cognition in people with APOE4, but it remains popular among carriers of the genetic variant, who hope it could help stave off dementia.Others have adopted episodic fasting. They draw hope from what’s known as the Nigerian paradox: Although the APOE4 allele is frequently found among elderly Nigerians, they’re not at increased risk of Alzheimer’s. African-Americans, by contrast, are just as likely to have the APOE4 allele, but develop the disease at much higher rates. The biggest difference in the populations is that the Nigerians have a lower incidence of cardiovascular disease — as well as lower levels of fats and cholesterol in their blood. So it’s possible that the Nigerian diet, which can include periods of low calorie intake, might protect against dementia. (There is some more general evidence that fasting can help prolong life, though the majority of the work has been conducted in animals.) ‘Beyond amyloid’: A look at what’s next in Alzheimer’s research “I’m nowhere as zealous or strict about my diet as some of our members. The idea of living life without a cucumber or tomato is depressing to me.” The concept of episodic fasting has won over George, a 62-year-old from Colorado who asked that only his first name be used to protect his privacy.He watched his mother decline from Alzheimer’s and then learned in 2009 that he carried the APOE4 gene. As it turns out, so does his wife. They consult regularly with Dr. Steven Gundry, a cardiothoracic surgeon by training who has written two diet books and sells a line of dietary supplements. (He has also backed actress Gwyneth Paltrow’s often less-than-scientific wellness site, Goop.) Among his controversial tips: Avoid foods containing lectins, such as tomatoes, peppers, beans, lentils, and pasta.George said the diet resonates with him: “I want to go back to the way our ancestors lived.”Every two weeks, he fasts for four to five days. He religiously tracks his food intake, and is constantly on the move. (He was the one doing cartwheels across the conference room to keep up his cardio.) George also regularly pays out of pocket to test a number of blood biomarkers, including sdLDL, a type of cholesterol that Gundry believes is a primary “mischief maker” in people with the APOE4 genetic variant. If George doesn’t like the number he sees on the lab readout, he tweaks his diet to try to raise or lower his sdLDL. “I’m probably more crazy than most people,” George conceded. Kale crackers and hibiscus tea: My five days on a ‘fasting diet’ Shelley Alvarado helps her dad, Joseph Gleason, take his jacket off at his retirement home. Sandy Huffaker for STAT Related: By Meghana Keshavan Aug. 22, 2017 Reprints SAN DIEGO — Everyone at the meeting had one thing in common: a ticking time bomb buried in their DNA.The engineers, physicians, financiers, and farmers gathered here this month all had learned through genetic testing that they carry a copy or two of APOE4, an allele of the gene APOE that substantially increases their risk of developing Alzheimer’s. It’s a disease with no good treatment, and no good prevention strategy. So carriers scour the internet to devise their own tactics for keeping their brains healthy: a high-fat diet. Episodic fasting. Oils. Supplements. Regular blood tests to monitor a specific type of cholesterol. Exercise, exercise, exercise — even including barefoot cartwheels across the conference room floor.Some of these ideas have modest scientific backing; others are more speculative. All are fair game for APOE4 carriers who are desperate to ward off the frightening tumble into dementia that they’ve seen afflict far too many of their relatives.advertisement White nationalists are flocking to genetic ancestry tests. Some don’t like what they find Mainstream scientists point out that such theories, while intriguing, are still far from validated. Gundry, for instance, said he has some anecdotal evidence but has published no rigorous clinical trials to back his views on using diet to forestall Alzheimer’s. And while there’s a whole cottage industry of books and games that promise to help preserve brain health, there just isn’t a lot of evidence behind it.“The data, I must say, is soft,” Mahley said. “It’s very hard to prove these lifestyle things. Lifestyle is a soft science, and nutrition is a soft science — because people respond to diets very differently.”Lacy visits with her dad at his retirement home. Sandy Huffaker for STATFighting to save every brain cellOutside of sharing some DNA, sisters Lacy and Alvarado don’t have a lot in common. Lacy’s a left-leaning psychiatrist, and a bit of a Buddhist. Alvarado, a surgical nurse, is fairly conservative and a devout Christian. They were never all that close, until recently — when they found out that they both carry APOE4. Having watched their parents decline, they know all too well what that could mean. Their father, a World War II vet, was a physician, and their mother helped found a school for autistic children in Long Beach, Calif. That school, Alvarado joked, was her mother’s fourth child — written in equally in her will. But their parents’ memories of their accomplishments have largely all gone now, and the sisters have been powerless to halt the progression of dementia. “These trials [of various diets] are expensive. If no money’s to be made with a little white pill, who’s going to fund them?” Researchers urge FDA to lower the bar — a little — on Alzheimer’s drug approvals The advent of low-cost genetic sequencing has opened up the secrets of our DNA — allowing us to learn about our Neanderthal origins, our tendency towards lactose intolerance, even (perhaps) our risk of developing tendon injuries when we work out. But that knowledge comes at a cost: Science often can tell us what diseases we’re predisposed to get, but not how to forestall them.A simple Google search about Alzheimer’s prevention turns up countless prospective remedies — and few answers. One site might suggest eating more blueberries, while another pushes coconut oil, and a third touts the virtues of oily fish. Amid the cacophony, the carriers gathered here for an APOE4 support group have, in effect, turned themselves into miniature science experiments, which they dub n=1 studies.advertisement [email protected] Related: @megkesh Tags agingdementiageneticsresearch Related: Related: Related: Biotech Correspondent Meghana covers biotech and contributes to The Readout newsletter. And while many APOE4 carriers believe that dietary changes offer hope for preventing the disease, it’s been difficult to test that theory, said Dr. Rudolph Tanzi, director of the genetics and aging research unit at Massachusetts General Hospital. He’s working with a company to develop a supplement for brain health, but said it’s much harder to find funding to test low-cost lifestyle interventions, such as cutting out carbohydrates.“These trials are expensive,” he said. “If no money’s to be made with a little white pill, who’s going to fund them?”Alvarado and her sister, Betty Gleason Lacy, with their father. The sisters both carry the APOE4 genetic variant, which has been linked to a higher risk of late-onset Alzheimer’s. Sandy Huffaker for STATTheories abound, but the science is scantA quick science lesson: The APOE gene gives the body instructions on how to produce a protein called apolipoprotein E. This protein ultimately helps regulate cholesterol levels in the blood. There are three major variants to the gene, called e2, e3, and e4. They only differ slightly. But the “very, very tiny” difference in APOE4 “has a profound effect on the way the protein is handled,” said Dr. Robert Mahley, an Alzheimer’s researcher at the University of California, San Francisco, who first discovered the APOE protein about 17 years back. It’s still largely not known how APOE4 increases the risk of Alzheimer’s. It is, however, associated with a buildup of protein clusters, called amyloid plaques, that accumulate in the brains of people with the disease. These toxic proteins can cause neurons to die, causing symptoms to progressively worsen.The disease has a number of co-risk factors — such as diabetes, smoking, and hypertension — so Mahley suggests that his patients control their cholesterol, maintain normal blood pressure, and aggressively treat their diabetes in hopes of reducing their chances of getting Alzheimer’s. But beyond such measures, science offers few answers to those with APOE4. Finding out you carry APOE4 can be terrifying. About 1 in 10 adults will develop Alzheimer’s by the age of 65; by age 85, that risk goes up to 50 percent. Carry one copy of the allele, and you have triple the likelihood to develop late-onset Alzheimer’s disease. Carry two copies, and your chances go up twelvefold. Sisters Betty Gleason Lacy and Shelley Alvarado are staring down that grim genetic math. They have a deep family history of Alzheimer’s: Their mother, grandmother, and great-grandmother all developed the condition. Their father, too, has dementia, though it likely has a different root.Each sister carries a single copy of APOE4. Their brother carries two. The sisters know how the disease can slowly take hold; they’ve seen their parents — once headstrong, accomplished, and independent — fade into shadows of their former selves. The pharmaceutical industry can offer no real hope: Drug after drug after drug has flopped in clinical trials. So Lacy is doing her own research, crisscrossing the country as a citizen scientist, attending conferences like this one to try to gain new insights from others with the APOE4 variant.“I feel very compelled to demystify this disease,” Lacy said. “We do not have to live with the old myth that there’s no hope, and there’s no cure.” The problem, of course, is that it’s not a myth: There is no cure for Alzheimer’s. Lacy tried to change her mother’s diet so that it more closely matches her own high-fat, low-carb approach — heavy on leafy greens, fish, nuts, and plant-based oils — but that’s proven near-impossible in her mother’s group home. So the daughters have decided that the next time their mother falls ill, they’ll let the infection take its course rather than fighting to keep her alive. That’s what she would have wanted. In the meantime, they’re sharing tips with new friends at the APOE4 meetup, which was organized to coincide with Low Carb USA, a dietary conference in San Diego. “We’re the canaries in the coal mine,” Alvarado said.The meetup was conceived by Julia Gregory, a former marriage counselor who discovered five years back that she carried two copies of the APOE4 gene. She was just about to turn 50, and had sent in a saliva sample to the genetic testing service 23andMe. She found her results were alarming, to say the least. And the advice she was given was certainly lacking: Her doctors could offer few suggestions beyond crossword puzzles and square dancing to prevent the onset of Alzheimer’s.So Gregory began to commiserate — and brainstorm — with the fellow APOE4 carriers she found on 23andMe’s forums. The participants shared lifestyle tips and research insights. Eventually, Gregory formalized the group into a nonprofit called APOE4 Info. Gregory now runs the organization full time, moderating the site’s online forum and consulting individually with people who have recently learned of their APOE4 status. She, too, experiments with her diet, but in moderation. “I’m nowhere as zealous or strict about my diet as some of our members,” she said. “The idea of living life without a cucumber or tomato is depressing to me.” Meghana Keshavan Dr. Rudolph Tanzi, Alzheimer’s researcher This year’s meetup drew a few dozen APOE4 carriers from around the world, who attended lectures suggesting a link between diabetes and Alzheimer’s and talked up their own experiments, often with technical proficiency that might rival a decorated neuroscientist.“I think I’m a much healthier person after having gotten involved in this group,” said Diana Ross, 83, a carrier who attended the meetup. She’s cut down on carbs and boosted her intake of vegetables and protein, and said her doctor has been pleased with the results.Members also discussed the broader implications of carrying APOE4, including the possibility of genetic discrimination. Alvardo, the surgical nurse, worries about how her peers will respond if she slips up at work: Will her colleagues read a momentary lapse of memory at face value, or as a sign of something deeper? As for Lacy, these days, she is expanding her psychiatric practice to serve a more geriatric population — by counseling patients on the lifestyle and dietary tips she’s trying out herself. It’s still a long shot, but she’s confident that these lifestyle changes will help.“I feel motivated,” she said, “to save every brain cell I can.” Lifestyle changes to stave off Alzheimer’s? Hints, no proof Julia Gregory, founder of APOE4 Info
Hills Hub – official opening Designed to respond to the emerging needs of residents in Cockatoo, Emerald, Gembrook and surrounding townships, the Hills Hub project delivers a beautiful, accessible and integrated space.The official opening of this fantastic new facility was held today (Monday December 14) and attended by representatives from each of the funding bodies and the Hills Hub Advisory Group.The official opening was held in accordance with Victorian Government COVID-19 restrictions and the Hills Hub COVIDSafe procedures and protocols, and a community celebration will be planned for the wider community with an open day when restrictions permit and it is safe to do so.Cardinia Shire Council Mayor Councillor Brett Owen said the Hills Hub brings together U3A Emerald, the Emerald Men’s Shed, Hills She Shed, Puffing Billy Toy Library, Emerald Village Association and many other wonderful community groups and not-for-profit organisations, under one roof, to improve access to a range of activities and services, increase social participation and strengthen community connections.“The facility also provides local businesses and training organisations with the opportunity to hire meeting, consulting and training rooms to support home and small businesses and enhance local training opportunities and pathways to employment.“The arts and performance space will accommodate an annual program of arts initiatives, activities and events, supporting existing and emerging artists and increasing local participation in and appreciation for local arts projects.“It is further envisaged that increased use of the precinct will benefit local cafes, shops and other businesses,” Cr Owen said.Cardinia Shire Deputy Mayor, Councillor Jeff Springfield said following detailed planning and working closely with our community, it is wonderful to celebrate the opening of the Hills Hub.“This beautiful, accessible and integrated facility will support a range of volunteer, community and local business initiatives and bring together several community groups and programs under one roof.“My sincere thanks goes to all members of the advisory group, the wider community and my councillor colleagues who have worked diligently to provide input on the design elements and key functions of this wonderful facility. The close partnership between Council, the community and key stakeholders has delivered an integrated and accessible community space where people of all ages and abilities can gather to learn, celebrate and connect.“I would also like to acknowledge the dedication and commitment of the Emerald Mechanic’s Institute over many years in managing the old hall for the benefit of the community. The Hills Hub will build on this legacy to ensure that residents of Cockatoo, Emerald, Gembrook and surrounding townships have access to a versatile and vibrant community gathering space for a range of events and activities.“Cardinia Shire Council has not just invested significantly in the building of this Community Hub, it has also committed to its activation through the appointment of a full-time Place Maker, who will work closely with local community organisations such as Emerald University of the Third Age (U3A) and the Emerald Men’s Shed to provide a range of activities and services to enhance community connections and promote health and wellbeing,” Cr Springfield said.The Hills Hub was funded through:Cardinia Shire $6.024 million Australian Government National Stronger Regions Fund $1.5 million Victorian Government Growing Suburbs Fund $1.5 million Dandenong Ranges Community Bank Group – Community Enterprise Foundation in partnership with the Eastern Dandenong Ranges Project Group $250,000 Hills Hub User Groups are looking forward to setting up and resuming service delivery over the summer months. Returning groups include: /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Australian, Australian Government, building, Cardinia, Cardinia Shire Council, Cockatoo, community, Dandenong, Emerald, employment, full-time, Gembrook, Government, local council, Owen, Springfield, university
New regional job precincts drive recovery in NSW Deputy PremierFour new Regional Job Precincts are coming to regional NSW to increase business and stimulate local economies post drought, bushfires and COVID, with the NEXUS Industrial Precinct in Albury named as the first.Deputy Premier and Minister for Regional NSW John Barilaro along with the Member for Albury Justin Clancy visited the NEXUS Industrial Precinct today to officially announce the first of four Regional Job Precincts to help drive recovery in NSW.“We need to drive investment to our regions, create new jobs and help our State to thrive again, and this is one way the NSW Government is doing exactly that,” Mr Barilaro said.“The formation of a Regional Job Precinct in Albury will see the NSW Government work with councils to reform existing planning processes and speed up development while maintaining existing environmental considerations so businesses can invest, create new jobs and boost the local economy.“The Regional Job Precincts are part of the NSW Government’s Special Activation Precinct program, initially with four established across the state based on site suitability and potential to deliver strong economic benefits.”Member for Albury Justin Clancy said the brand new Regional Job Precinct would be a game-changer for job creation and industry investment in Albury and surrounds.“Albury’s enviable location along the major transport corridor between Sydney and Melbourne means there are incredible opportunities in freight and logistics, agribusiness and manufacturing industries in the NEXUS Precinct,” Mr Clancy said.Albury City Mayor, Kevin Mack said the new initiative is a great win for the community and would boost business growth and job opportunities right across the Albury region.“This is a fantastic opportunity for the council to partner with the NSW Government to drive meaningful planning reforms that will encourage investment and benefit potential and existing investors in the region, building on the work already done as part of the Albury-Wodonga regional deal,” Mr Mack said.Further locations for Regional Job Precincts will be announced in coming months. Regional Job Precincts are part of the Special Activation Precincts program and the $4.2 billion Snowy Hydro Legacy Fund, which is dedicated to transformative infrastructure projects across regional NSW.Find out more about the Regional Job Precincts /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Albury, Australia, building, bushfires, business, community, drought, Government, industry, infrastructure, Investment, Melbourne, Minister, New South Wales, NSW, Premier, Sydney, Transport
A Special Memorial Day Observance for 2020Posted by ClarkCountyToday.comDate: Friday, May 22, 2020in: Newsshare 0 CVTV will broadcast a special program, prepared in advance and airing Monday at 3 p.m. and 9 p.m.VANCOUVER — The Community Military Appreciation Committee (CMAC), the city of Vancouver, and the National Park Service will present Vancouver’s Memorial Day Observance Mon., May 25, sponsored by Waste Connections. This year, the event which has brought thousands to the national park’s parade ground annually, will be quite different than in years past, as veterans will be honored while participants also respect social distancing protocols during the COVID-19 pandemic.National park rangers raise the large garrison flag on the Vancouver Barracks Parade Ground on Flag Day, 2018. Photo courtesy of National Park Service/Junelle LawryCVTV will broadcast a special program, prepared in advance and airing Monday at 3 p.m. and 9 p.m., featuring remarks by Larry Smith and Mike Burton, representing CMAC, Tracy Fortmann, the superintendent of Fort Vancouver National Historic Site, Vancouver Mayor Anne McEnerny-Ogle, as well as Meredith McMackin, a Gold Star Mother. The keynote speaker will be Gen. Donna Prigmore of the Oregon National Guard. Speakers are recording their messages separately and many chose to be filmed in locations meaningful to veterans and local military history. The program will also be available on CVTV cable channel 23/323HD and on www.cvtv.org.Music within the broadcast program, filmed in advance, will be provided by the 204th Army Band, Vancouver FireFighters Pipes and Drums, Vancouver Police Department, and VFW Post 7824 Honor Guard.Fort Vancouver National Historic Site Superintendent Tracy Fortmann said, “The coronavirus pandemic prevents us from gathering this year together as we normally would, but consistent with guidance from national, state, and local public health authorities, we are safely observing Memorial Day. By videotaping speakers’ remarks this year from different locations, we are responsibly doing our part for our community, our health care heroes, other front-line workers and first responders, and those who are vulnerable.”CMAC Co-Chair Larry Smith stated, “The Memorial Day Observance honors those who have given their lives for our country, and although not the public event and living history re-enactment we have enjoyed in the past, we still have an opportunity to show our respect and support for the men and women of our armed forces.”Vancouver Mayor Anne McEnerny-Ogle stated, “It was so very important that we – as a community – observed Memorial Day this year, and we are taking the time to reflect and recognize, in a safe manner, our fallen soldiers who have given all to our nation.”CMAC is an all-inclusive group composed of members representing youth, education, civic, military, veterans groups, and local governments. CMAC executes and plans community-wide events, such as Memorial Day, Veterans Day, Our Community Salutes, and POW/MIA Day ceremonies, as well as recognition and support of military families of all services. Learn more about CMAC at www.cmac11.com.Information provided by Fort Vancouver National Historic Site and National Park Service.AdvertisementThis is placeholder textTags:Clark CountyLatestVancouvershare 0 Previous : City of Battle Ground to Commemorate Memorial Day Next : WATCH: Clark County TODAY LIVE • Friday, May 22, 2020AdvertisementThis is placeholder text
Pinterest ReddIt Facebook Twitter Linkedin Home Industry News Releases A to Z Wineworks Appoints Leslie Kruempel as Director of MarketingIndustry News ReleasesWine BusinessA to Z Wineworks Appoints Leslie Kruempel as Director of MarketingBy Press Release – October 6, 2020 337 0 Previous articleGeographical Digest Continues Bringing the World of Wine to OenophilesNext articleWinemakers Agree, Pinot Noir Is a Perfect Pairing for the Thanksgiving Table Press Release TAGSA to Z WineworksLeslie Kruempelpeople Share Email AdvertisementA to Z Wineworks, Oregon’s best-selling wine brand, is pleased to welcome Leslie Kruempel as Director of Marketing. Leslie will manage brand and creative initiatives that elevate the consumer connection as A to Z’s business continues to expand.Deb Hatcher, Founding Partner and Chief Marketing Officer for A to Z Wineworks said, “Leslie is a purpose driven marketing and communications leader with proven success in one of the most competitive food and beverage categories. We look forward to continue advancing our marketing strategy together.”Leslie brings over 10 years of experience in the food and beverage industry, many of which were in marketing and mission leadership positions for Organic Valley, one of the nation’s leading organic brands. After building Organic Valley’s social media program from the ground up, she led high-engagement marketing campaigns that won Effie, Addy and Webby awards. “It’s fulfilling to join a company that not only makes fantastic wine, but does so while partnering commerce with conscience,” said Leslie. “I’m eager to help more people find A to Z Wineworks as they look to spend their dollars with companies working to improve the world.”About A to ZSince 2002, A to Z Wineworks has been offering “The Essence of Oregon” by sourcing from vineyards across the state and carefully blending wines true to their variety. 100% Oregon sourced and based, A to Z sets the standard for cool climate, food-enhancing Pinot Noir, Pinot Gris and Chardonnay. In 2014 A to Z Wineworks became a certified B Corporation and has been recognized as a ‘Best for the World’ company every year since. A to Z Wineworks is an equal opportunity employer and works toward racial equity and inclusion. The company is based in Newberg, Oregon at their REX HILL property. To learn more visit www.AtoZwineworks.comAdvertisement
Menopause to become the next game-changer in global femtech solutions industry by 2025 Share Related Posts MaxiVision Eye Hospitals launches “Mucormycosis Early Detection Centre” By Sanjiv Das on May 19, 2018 Students who want to pursue a career in paramedic and allied healthcare courses will be benefittedKissht, a fintech EMI payment and digital lending platforms announced its partnership with VIVO Healthcare (VIVO), a leading healthcare education and training company to provide easy finance options for short-term courses across all training centres in India. This agreement will help students who want to pursue a career in paramedic and allied healthcare courses. The uniqueness of this offering is that students will get easy finance without submitting any collateral.Through this easy finance loan options, students can opt for courses like emergency medical technician, dialysis technician, dental assistant, X-Ray technician, radiology technician, cardiac care technician, medical lab technician, operation theatre technician provided by VIVO.With training centres in 35 cities across 18 states, VIVO provides skill-based employability training for the healthcare industry. In addition, VIVO offers many community based healthcare training programmes such as life support, emergency response, and health and safety courses for schools, corporates, hospitals and government bodies.Speaking on this occasion, Krishnan Vishwanathan, CEO and the Founder, Kissht says, “VIVO Healthcare provides huge employment opportunities to its students looking to make a career in the healthcare industry. Keeping in line with VIVO Healthcare’s mission of Skilling India to Save Lives, we hope that with Kissht’s quick loan finance and easy EMI payment, there will be an increase in the number of students signing up for these courses.”“Educational loans are a key driver to enabling more and more students to access quality skill based training and thereby getting employment in the fast growing healthcare industry. Kissht’s innovative credit scoring platform will allow many first time borrowers to access loans for their educational requirements across all our training centres, added Mohit Mehra, COO, VIVO Healthcare. Read Article The missing informal workers in India’s vaccine story Heartfulness group of organisations launches ‘Healthcare by Heartfulness’ COVID care app Indraprastha Apollo Hospitals releases first “Comprehensive Textbook of COVID-19” News WHO tri-regional policy dialogue seeks solutions to challenges facing international mobility of health professionals Kissht partners with VIVO Healthcare Phoenix Business Consulting invests in telehealth platform Healpha
Retrospect can be a professional golfer’s worst enemy. In hindsight, the slightest miscue can be painfully overanalyzed and that microscope becomes even more intense when the stage is the most scrutinized patch of turf in the entire game. Nearly a dozen contenders made their way through Amen Corner during the final round of last year’s Masters Tournament with at least an outside chance for victory, and nearly all of them came unraveled at the par-3 12th hole. News & Opinion Watching Tiger’s Masters win on TV after seeing it first-hand BY Ryan Lavner — April 6, 2020 at 8:00 AM Witnessing Tiger Woods win the 83rd Masters first hand was unforgettable, but watching it for the first time on TV was revealing. Under normal circumstances, that is to say, any turn that wouldn’t include a handshake in Butler Cabin followed by a green jacket fitting, the 155-yard hole perched on the edge of Rae’s Creek is little more than a seamless transition from the risk of the par-4 11th hole to the reward of the par-5 13th. “If there’s no wind it just depends if you hit a good shot. There’s nothing really that can stop you from hitting that green,” Francesco Molinari figured earlier this year. “I remember like the Saturday last year, I think I hit it a few inches from the hole with obviously a different pin position.” Last year, No. 12, dubbed “Golden Bell,” ranked squarely in the middle of the pack as the week’s ninth toughest hole with a 3.05 scoring average. Photos Augusta National: Hole-by-hole, flowery names A hole-by-hole look at Augusta National, home of the Masters Tournament, including the flowery names for each. But Sunday was different. Sunday at the Masters is always different. Of the top 11 players on the final leaderboard from the 2019 Masters there wasn’t a single birdie made, and the group was a collective 7 over par for the day on No. 12. It all added up to Golden Hell — sorry, Golden Bell — playing to a 3.34 average and the day’s toughest hole in a particularly brutal final round. Getty Images Playing in the day’s penultimate group ahead of Molinari, Tiger Woods and Tony Finau, Brooks Koepka seemed to set the tone for the 12th hole. Cruising along at 11 under par (the winning score would be 13 under), Koepka’s tee shot drifted dangerously to the right, brushed the bank just short of the green and bounded into the creek. He made a double bogey and would finish tied for second place, a stroke out of the lead. Playing with Koepka, Ian Poulter’s tee shot suffered a similar fate and he made double bogey. Both Molinari and Finau’s tee shots also found the creek (bookend double bogeys to Tiger’s par) and Woods emerged from the 12th with a share of the lead. “Sunday, when the wind is up and I think especially it was coming kind of into, from behind the green and those huge trees behind the green, so you never know how much wind actually it’s going to get,” Molinari conceded. “It’s just complicated.” Every player agrees the 12th is a “complicated” hole, but why it creates such a unique challenge depends on who’s swinging the club. Weather conditions created much of the guess work Sunday a year ago. The forecast led to Augusta National officials to move up tee times and send players off the first and 10th tees in threesomes to avoid an approaching storm. It was a shrewd and surprising move that allowed the tournament to avoid a delay, but it also led to some of the most challenging conditions in recent years. Winds from the southeast gusted to 25 mph as the final groups approached Amen Corner and swirled through the famous pines as each contender stepped to the 12th tee box with the traditional back-right Sunday hole location. “It’s the hardest wind for that hole, in and off the left. Even though it wasn’t howling it was enough to impact the golf ball for a lot of us coming down the stretch,” Finau said. “It’s just the hardest wind to play that hole. I’d prefer straight in or straight in and off the right to that green. The way the green is angled you don’t want the wind to come off the left.” Getty Images Molinari, who was 13 under par and in control of the tournament until the fateful 12th hole, agreed that the wind direction created an imperfect storm for every contender, but the Italian also acknowledged the gravity of the moment. “The situation, too; you get there, it’s Sunday afternoon, so I think a few of us hit in the water that day and, yeah, it shows how tough it was playing,” Molinari said. “That’s the beauty of the Masters and Amen Corner.” And then there’s the question of situational awareness and experience. For Woods, who would birdie three of the next four holes to win by a shot, it was his 22nd start and fifth victory at Augusta National. Of the remaining 10 players within the top 11 on the final leaderboard none had more than nine starts at the Masters. Woods also had the benefit of watching the carnage unfold in the final two groups. “[Finau] hit the best shot of all of us and he got stood up at the very end. It was a good shot. He hit it flush, but it stalled out at the top,” Woods said. “If I had gone at the flag, my ball would have done the same thing, because mine, I played left, and it stalled out at its apex, ended up short left, and I had a putt.” Unlike many of the would-be champions, Woods erred on the left side of the narrow green that angles away from the tee box and plays longer the farther right you attempt to aim. Getty Images “Watching [Molinari] hit an 8-iron there, and you could see it, and I know he didn’t quite hit it right, but I played it to the left,” Woods said. It was a pivotal moment and quintessential Tiger. Stewart Cink once said Woods was at his best when he was playing “prevent defense” and allowing those around him to fall away with unforced errors. Denis Pugh, Molinari’s swing coach, remembers watching the dynamic between Woods and the rest of the field flip in an instant as he loomed larger than life near his golf ball safely in the middle of the 12th green: “[Molinari] is waiting to hit his chip [third shot] and Tiger is waiting on the green. It’s where Tiger took control of the tournament like he always did,” Pugh recalled. Maybe Finau should have hit an 8-iron off the 12th tee. Maybe Molinari should have aimed farther left of that diabolical hole location. Maybe officials should have doggedly clung to tradition and sent players out in twosomes off the first tee. For those prone to hindsight it can be a brutal arbiter.
Notes Michael J. BeheSenior Fellow, Center for Science and CultureMichael J. Behe is Professor of Biological Sciences at Lehigh University in Pennsylvania and a Senior Fellow at Discovery Institute’s Center for Science and Culture. He received his Ph.D. in Biochemistry from the University of Pennsylvania in 1978. Behe’s current research involves delineation of design and natural selection in protein structures. In his career he has authored over 40 technical papers and three books, Darwin Devolves: The New Science About DNA that Challenges Evolution, Darwin’s Black Box: The Biochemical Challenge to Evolution, and The Edge of Evolution: The Search for the Limits of Darwinism, which argue that living system at the molecular level are best explained as being the result of deliberate intelligent design.Follow MikeProfileWebsite Share Email Print Google+ Linkedin Twitter Share Photo: Tap dancing, Iowa State College, 1942, by Jack Delano, Public domain, via Wikimedia Commons.Editor’s note: We are delighted to celebrate the publication of the new book A Mousetrap for Darwin: Michael J. Behe Answers His Critics. What follows is an excerpt, drawn from “Irreducible Complexity: Obstacle to Darwinian Evolution,” in Debating Design: From Darwin to DNA, eds. William Dembski and Michael Ruse (New York: Cambridge University Press, 2004). Congratulations to Science Magazine for an Honest Portrayal of Darwin’s Descent of Man TagsAmerican Museum of Natural Historybacterial flagellumBrown UniversityCambridge University PressDarwinian processesDarwinismDebating DesignfunctionIrreducible ComplexityJohn McDonaldJohn PolkinghorneKenneth Millerkey chainMichael RuseNational Center for Science EducationpaperweightpartsPaul DaviesRichard Swinburnerotary propulsionStuart Kauffmantoothpickstype III secretion systemWilliam Dembski,Trending “Forum on ‘Intelligent Design’ Held at the American Museum of Natural History (April 23, 2002).”Shin-Ichi Aizawa, “Flagellar Assembly in Salmonella typhimurium,” Molecular Microbiology 19 (January 1996): 1–5.Christoph J. Hueck, “Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants,” Microbiology and Molecular Biology Reviews 62 (1998): 379–433. Email Print Google+ Linkedin Twitter Share Evolution A Brazen Equivocation With the problem of the mousetrap behind him, Miller moved on to the bacterial flagellum — and again resorted to the same fallacy. If nothing else, one has to admire the breathtaking audacity of verbally trying to turn another severe problem for Darwinism into an advantage. In recent years it has been shown that the bacterial flagellum is an even more sophisticated system than had been thought. Not only does it act as a rotary propulsion device; it also contains within itself an elegant mechanism to transport the proteins that make up the outer portion of the machine, from the inside of the cell to the outside.2 Without blinking, Miller asserted that the flagellum is not irreducibly complex because some proteins of the flagellum could be missing and the remainder could still transport proteins, perhaps independently. (Proteins similar — but not identical — to some found in the flagellum occur in the type III secretory system of some bacteria.3) Again he was equivocating, switching the focus from the function of the system to act as a rotary propulsion machine to the ability of a subset of the system to transport proteins across a membrane. However, taking away the parts of the flagellum certainly destroys the ability of the system to act as a rotary propulsion machine, as I have argued. Thus, contra Miller, the flagellum is indeed irreducibly complex. What’s more, the function of transporting proteins has as little directly to do with the function of rotary propulsion as a toothpick has to do with a mousetrap. So discovering the supportive function of transporting proteins tells us precisely nothing about how Darwinian processes might have put together a rotary propulsion machine. Jane Goodall Meets the God Hypothesis Intelligent Design Excerpt: An Obstacle to Darwinian EvolutionMichael BeheDecember 18, 2020, 6:43 AM Recommended Our Debt to the Scientific Atheists A Physician Describes How Behe Changed His MindLife’s Origin — A “Mystery” Made AccessibleCodes Are Not Products of PhysicsIxnay on the Ambriancay PlosionexhayDesign Triangulation: My Thanksgiving Gift to All Origin of Life: Brian Miller Distills a Debate Between Dave Farina and James Tour “A Summary of the Evidence for Intelligent Design”: The Study Guide Of course the facile explanation rests on a transparent fallacy, a brazen equivocation. Miller uses the word “function” in two different senses. Recall that the definition of irreducible complexity notes that removal of a part “causes the system to effectively cease functioning.” Without saying so, in his exposition Miller shifts the focus from the separate function of the intact system itself to the question of whether we can find a different use (or “function”) for some of the parts. However, if one removes a part from the mousetrap I pictured, it can no longer catch mice. The system has indeed effectively ceased functioning, so the system is irreducibly complex, just as I had written. What’s more, the functions that Miller glibly assigns to the parts — paperweight, toothpick, key chain, etc. — have little or nothing to do with the function of the system of catching mice (unlike the mousetrap series proposed by John McDonald), so they give us no clue as to how the system’s function could arise gradually. Miller explained precisely nothing. Rather than showing how their theory could handle the obstacle, some Darwinists are hoping to get around irreducible complexity by verbal tap dancing. At a debate between proponents and opponents of intelligent design sponsored by the American Museum of Natural History in April 2002, Kenneth Miller actually claimed (the transcript is available at the website of the National Center for Science Education1) that a mousetrap isn’t irreducibly complex because subsets of a mousetrap, and even each individual part, could still “function” on their own. The holding bar of a mousetrap, Miller observed, could be used as a toothpick, so it still had a “function” outside the mousetrap. Any of the parts of the trap could be used as a paperweight, he continued, so they all had “functions.” And since any object that has mass can be a paperweight, then any part of anything has a function of its own. Presto! — there is no such thing as irreducible complexity! Thus the acute problem for gradualism that any child can see in systems like the mousetrap is smoothly explained away. Author’s note: Whenever professors get together to talk, somebody eventually says, “Hey, let’s write a book on this!” (We get to add it to our CVs.) For Debating Design, the philosopher of biology Michael Ruse and design theorist William Dembski gathered contributions in 2004 from some true academic luminaries: geneticist Francisco Ayala, philosopher of science Elliott Sober, complexity theorist Stuart Kauffman, physicist Paul Davies, theologians John Polkinghorne and Richard Swinburne, and more. Also included were Brown University biologist Kenneth Miller and myself, taking shots at each other.