Iranian oil sanctions loom as US gears up for ‘toughest sanctions regime ever imposed’

first_img whatsapp Tags: Twitter Crude prices hit a three-month low yesterday after the White House said that it will be allowing eight countries to import limited amounts of Iranian oil in a bid to keep markets stable.Fears of supply shortages simmered down as US Secretary of State Mike Pompeo said that Washington was granting eight wavers.The move follows on from months of volatility within the oil markets, which has mounted on the back of mounting tensions between President Rouhani and President Trump.Crude prices fell back to a three-month low yesterday following the comments, although the White House said has since reiterated its stance that the sanctions will be the toughest ever imposed on Tehran.In a reference to TV series of Game of Thrones and its motto “Winter is coming”, Trump tweeted on Friday: “Sanctions are coming” whatsapp Iranian oil sanctions loom as US gears up for ‘toughest sanctions regime ever imposed’ Saturday 3 November 2018 10:55 am More From Our Partners Supermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.com980-foot skyscraper sways in China, prompting panic and evacuationsnypost.comI blew off Adam Sandler 22 years ago — and it’s my biggest regretnypost.comKiller drone ‘hunted down a human target’ without being told tonypost.com‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comUK teen died on school trip after teachers allegedly refused her pleasnypost.comMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comWhy people are finding dryer sheets in their mailboxesnypost.comMark Eaton, former NBA All-Star, dead at 64nypost.comcenter_img Sebastian McCarthy Share Politicians and businesses are bracing themselves for new US sanctions on Iranian oil that are set to come into effect on Monday, in what the White House has branded as its “toughest ever” measures imposed on Tehran.The US is planning to reinstate all US sanctions on Iran removed under the 2015 nuclear deal, in a move that has sent geopolitical shockwaves throughout the world. pic.twitter.com/nk2vKvHuaL— Donald J. Trump (@realDonaldTrump) November 2, 2018Trump withdrew from the US nuclear agreement in May, which was signed in 2015, branding the deal “defective” because it had failed to prevent Iran from developing a ballistic missile programme. last_img read more

News / Shipping lines in financial trouble pose a risk to our supply chains, claim shippers

first_imgBy Gavin van Marle in Hamburg 15/06/2016 Mr Neise added that shipping lines needed to imitate freight forwarders and offer a greater range of services, as well as differentiate their offering from competitors.“What we are seeing in the 3PL sector is that they differentiate their services, such as guaranteeing on-time deliveries. And we are always asked whether we would pay for this: yes we would, in fact we already do with our 3PLs.”But he added: “I’m of the opinion that more and more carriers are simply focused on their core business and not taking the end-to-end view. But we, as a shipper, are only interested in the end-to-end view of the supply chian.”Filip Degroote, EMEA transportation director for Stanley Black & Decker, told The Loadstar: “Carriers’ problems pose huge difficulties for us.“We currently have cargo with Hanjin, and so are monitoring its situation daily, because the danger is that cargo could get blocked and it is extremely difficult to retrieve it.“In a lot of cases, these goods are already sold to our customers and we are not able to manufacture them again, because everything we do is based around inventory, and we are selling out of that inventory to customers who are waiting for their goods.“This isn’t just restricted to ocean transport. Last year I had two tier-one road transport providers who went bankrupt which resulted in cargo getting blocked, causing huge disruption to our supply chain.”Mr Degroote said Black & Decker had traditionally employed 3PLs to manage its supply chain, but due to continuing pressures on inventory it was now building its own LCL boxes, and was increasingly looking to contract directly with carriers.“However, if carriers want to play a bigger role with Black & Decker, they will need to provide some of the services the 3PLs provide,” he said. Major shippers are calling on shipping lines to develop a greater range of services and claim carriers experiencing financial difficulties pose a huge risk to their supply chains.Rolf Niese, until recently head of logistics operations at British American Tobacco, told delegates at the TOC Container Supply Chain event that many shippers had “celebrated” the lowest freight rates seen in living memory.But he added that the recent surge in consolidation in the sector presented huge challenges to those operating global supply chains.He told delegates in Hamburg this week: “With all the M&A activity there is a lot of uncertainty. Firstly, we are not well informed: we do not who is cooperating with whom, and where; or which carriers are on the M&A list.“This is a huge risk for us,” he said.last_img read more

They built a game-changing cancer-killing therapy. Now they’re taking on a new kind of CAR-T therapy

first_img Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. What is it? NIH The two former Kite Pharma executives behind a game-changing cancer-killing technology are launching their next act: a new company to develop a suite of so-called off-the-shelf CAR-T therapy assets, designed so that they do not need to be personalized for each cancer patient.Allogene Therapeutics, which was unveiled Tuesday morning, has raised $300 million to acquire and advance a portfolio of experimental cell therapies previously controlled by Pfizer. As a consequence of the deal, Pfizer is getting out of the business of being a major CAR-T player, though it will take a 25 percent ownership stake in Allogene. Biotech Log In | Learn More They built a game-changing cancer-killing therapy. Now they’re taking on a new kind of CAR-T therapy By Rebecca Robbins April 3, 2018 Reprints GET STARTED What’s included? STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Tags biotechnologylast_img read more

JOB VACANCY: Telfords in Portlaoise and Mountrath are looking to fill a key position

first_imgHome Jobs JOB VACANCY: Telfords in Portlaoise and Mountrath are looking to fill a… JobsSponsored WhatsApp Laois County Council create ‘bigger and better’ disability parking spaces to replace ones occupied for outdoor dining Facebook Laois County Council team up with top chef for online demonstration on tips for reducing food waste Twitter JOB VACANCY: Telfords in Portlaoise and Mountrath are looking to fill a key position Twitter Ten Laois based players named on Leinster rugby U-18 girls squad Telfords are currently seeking applications for the following opportunity.Job TitleStock ControllerRequirementsMinimum of 3 years’ experience in Stock Control of Building Materials & Electrical Appliances.A high level of IT skills, including experience of MS Office.Excellent numerical and Data entry skills.Excellent communication, interpersonal, planning and organisational skills.Attention to detail.LocationBased in both our Portlaoise and Mountrath branch.If you believe you can supply the above, please apply by email to [email protected] and subject to be marked “Job Application”Closing Date: 20th March 2018SEE ALSO – Check out the job section on LaoisToday.ie Pinterest Pinterest WhatsApp RELATED ARTICLESMORE FROM AUTHOR Facebook Previous articleIn Pictures: The craic is mighty as the Laois party in London gets underwayNext articleDeaths in Laois – Sunday, March 11, 2018 LaoisToday Reporter Rugby Council By LaoisToday Reporter – 11th March 2018 TAGSTelfords Community last_img read more

Park-Ratheniska/Timahoe earn coveted semi-final place and Rathdowney-Errill knock out Kyle in the JHC

first_img Previous articleThe Week that Was: The top 10 stories of the past seven daysNext articleCollier to the fore as Camross see off 14 man Trumera LaoisToday Reporter Park-Ratheniska/Timahoe earn coveted semi-final place and Rathdowney-Errill knock out Kyle in the JHC GAA By LaoisToday Reporter – 4th August 2019 GAA Twitter GAA Kelly and Farrell lead the way as St Joseph’s claim 2020 U-15 glory WhatsApp It was then time for more goals to come into the fore. Pa Foyle was next to raise the green flag for PR/T, before Paddy Kelly, aided by great work from two more Foyles, Joe and Robbie, hit the net to make it 3-6 to Abbeyleix’s two.A combination of Robbie Foyle frees and a shot from Mick Brennan brought PR/T up to a seventeen point lead at the break – 3-12 to four points.The scores didn’t stop there. Damien O’Connor sailed over a monster of a point, while Foyle was unstoppable from raising the white flag.This lead built up to 23 points as the clock ticked over into the 20th minute.However a goal and a handful of scores from the home side did manage to cut this lead back to 16 but the game was well over by then, with P/R-Timahoe emerging a reosunding winners who now go through to the junior A semi-finals.Rathdowney-Errill 1-18 Kyle 0-8Laois Shopping Centre JHC ‘A’ Round TwoRathdowney-Errill at any grade is a tough encounter, and a Kyle team down on their numbers felt this today with a 13 point defeat to the home side in Errill.Rathdowney-Errill corner-forward Mick Bowe rattled the net for the only goal of the game ten minutes from the throw-in to mark his name in the books for the victors.This, coupled with Liam O’Connell’s efforts from placed balls along with Gavin Delaney and Brian Meehan raising the white flags, left the home side six points in the lead on 1-8 to 0-5 at the interval.Rathdowney-Errill went in six point leaders at half-time, but they made hay playing into a strong breeze in the second half to come out resounding victors.Dan Bourke managed a monster of a score from the first breaking ball, his 60 yard shot coming from the throw-in on the resumption of the game.It was Gavin Delaney and Brian Meehan again at the fore on the scoring front, putting up two points a piece while centre-forward O’Connell pointed three, two from frees.Ray Kelly came in off the bench with impact, slotting over the final two points of Rathdowney-Errill’s 1-18 to set them up for a place in the quarter-finals.SCORERS – Rathdowney-Errill: Mick Bowe 1-0, Liam O’Connell 0-7 (0-2 frees, 0-1 65′), Gavin Delaney 0-4, Brian Meehan 0-3, Ray Kelly 0-2, Dan Bourke 0-1, Paddy Carroll 0-1 Kyle: Conor Quinlan (frees), Adam FitzpatrickRATHDOWNEY-ERRILL: JP Ryan; Patrick Wright, John Delaney, Sean Meehan; Eoin Fitzpatrick, Niall Delaney, Dylan Delaney; Dan Bourke, Adam Loughman; Matt Meehan, Liam O’Connell, Gavin Delaney; Paddy Carroll, Brian Meehan, Mick Bowe. Subs: Ray Kelly for P Carroll, Colm Ryan for M Bowe, Mark Dunne for L O’Connell, Emmet Gilmartin for D DelaneyKYLE: Eoin Kennedy; Adrian Morrissey, Eamon Fletcher, Cronan Murphy; Gary Finnerty, Michael Gilmartin, Robert Phelan; Kevin Grady, Paul Scully; Darragh Morrissey, Conor Quinlan, Darren Clavin Morrissey; Adam Fitzpatrick, Francis Harte, Miles DelaneySEE ALSO – Linehan goal crucial as Mountrath beat 14-man Colt in SHC ‘A’ opener Here are all of Wednesday’s Laois GAA results Facebookcenter_img Pinterest Twitter TAGSAbbeyleix St Lazarians vs Park-Ratheniska/TimahoeKyleKyle GAALaois JHC ‘A’Park-Ratheniska-TimahoeRathdowney-ErrillRathdowney-Errill vs Kyle Pinterest Facebook RELATED ARTICLESMORE FROM AUTHOR Photo: Brian Ramsbottom Park-Ratheniska/Timahoe 3-20 Abbeyleix 1-10Laois Shopping Centre JHC ‘A’ Round TwoGoals and a stellar first half performance were key in Park-Ratheniska/Timahoe’s opening round win in the junior A competition and they were just as vital today, building up an almost insurmountable 17 point lead over Abbeyleix at the half-time break.A third minute goal from Robbie Foyle set up Park-Ratheniska/Timahoe to take an early lead, one they wouldn’t  relinquish in this round two clash.Padraig Kelly aided Park-Ratheniska/Timahoe’s scoring efforts, with Foyle sending over a free to launch six points ahead – 1-5 to 0-2 after nine minutes. Home Sport GAA Park-Ratheniska/Timahoe earn coveted semi-final place and Rathdowney-Errill knock out Kyle in the… SportGAAHurling 2020 U-15 ‘B’ glory for Ballyroan-Abbey following six point win over Killeshin WhatsApplast_img read more

Deaths in Laois – Tuesday, March 10, 2020

first_img Electric Picnic organisers release statement following confirmation of new festival date Electric Picnic Laois Councillor ‘amazed’ at Electric Picnic decision to apply for later date for 2021 festival RELATED ARTICLESMORE FROM AUTHOR Facebook Previous articleLaois County Council: Expressions of Interest for the Provision of Occupational Therapist ServicesNext articleTwo Laois designs through to coveted All-Ireland Junk Kouture Final LaoisToday Reporter WhatsApp Below are the recent deaths in Laois.Ar Dheis De go raibh a anam.Elizabeth Curtis (née O’Keeffe)Larkfield, Athy, Kildare, R14 DH24 / Stradbally, LaoisMother of the Late Cath. Deeply regretted by her loving husband Johnny, sons Mick, Bren, John, Lar, Dan & Darren, daughters Helen, Mag, Trisha, sister Marie, sons-in-law, daughters-in-law, grandchildren, great-grandchildren, nieces, nephews, relatives and friends.Rest in PeaceReposing at her residence on Monday and Tuesday with Rosary on both evenings at 8pm. Removal by Rigney’s Funeral Directors on Wednesday afternoon at 2.15pm to arrive at the Sacred Heart Church, Stradbally for Requiem Mass at 3pm. Burial afterwards in Oakvale Cemetery, Stradbally.Mary Walsh (née Phelan)Erkindale Drive, Durrow, LaoisPeacefully surrounded by her husband Andy and loving family after a long illness borne with great dignity and strength. Predeceased by her darling son Shane, and sister Eileen.Deeply regretted by her husband Andy, sons Andrew, Pat, Jason & Jonathan daughters Maureen, Vicky, Amy, Eve and Cathy, her twenty grand-children, sons-in-law, daughters-in-law, brother Larry, sister Joan, brothers-in-law Nicky and Mick, sisters-in-law Angela and Marie, nieces, nephews, cousins and the Entire Community of Durrow.May she Rest in PeaceReposing at her residence from 3 pm Tuesday with Rosary at 8pm. Removal Wednesday morning arriving at the church of the Holy Trinity for 12 o’ clock Requiem Mass. Burial immediately afterwards in the adjoining cemetery. House Private Wednesday Morning Please.Family Flowers only. Donations in lieu to the Irish Cancer Society.Edward Ned Carroll13 Killimy Road, Emo, LaoisNed died, peacefully, in his home, in the loving care of his family. Predeceased by his daughter Valerie. Deeply regretted by his loving sons and daughters, Terry, Martin, Caroline, Rose-Marie, Imelda, Regina, Edwina, Edmund and Anthony, grandchildren, great-grandchildren, sons and daughters in-law, brothers Miley, Larry and Tony, sisters Breda and Julie, nieces and nephews, neighbours, relatives and many friends.Rest In PeaceReposing in his home on Monday from 5pm. Recital of the rosary 8pm. Funeral arriving at St. Paul’s Church, Emo, on Tuesday for 12 noon Requiem Mass. Burial afterwards in St. Paul’s New Cemetery. Family time in the home on Tuesday morning.John DillonEmmet Street, Mountmellick, LaoisJohn Dillon, Emmet Street, Mountmellick, Co.Laois. Died March 8th, peacefully, at The Regional Hospital, Portlaoise, surrounded by his loving family.Funeral Arrangements LaterMary EyreNo 2 Orchard Lane, Leighlinbridge, Carlow/Bilboa, Carlow/LaoisMary Eyre, No. 2 Orchards Lane, Leighlinbridge and formerly Gurtahile, Bilboa, Co. Carlow passed away peacefully, on 7th March, 2020, surrounded by her loving family, at The District Hospital, Carlow.Predeceased by her parents Henry and Mary and her sister Rosemary.She will be deeply regretted and sadly missed by her loving brothers Richard, Harry, John and Christy, sisters Teresa, Bernadette, Kathleen, Helen and Margaret, brothers-in-law, sisters-in-law, nephews, nieces, grandnephews, grandnieces, cousins, relatives and her many friends.Reposing at Carpenter Bros Funeral Home, Barrack St., Carlow, on Monday from 12 noon with removal that evening at 6.45pm to The Church of Blessed Virgin Mary, Mayo, Co. Laois arriving at 7.30pm. Funeral Mass on Tuesday at 12 noon followed by burial in the adjoining cemetery.Donations, in lieu of flowers, to The Friends of the District Hospital, Carlow.Patrick Culbert4 Harbour Court, Mountmellick, LaoisPatrick died unexpectedly in his home in England. Beloved son of Patrick Culbert and Jenny Wheeler and dear brother of Sinead, Phillip and Kenneth. Deeply regretted by his loving parents, sister, brothers, family circle, relatives and many friends.Rest in PeaceFuneral arrangements will be announced later.SEE ALSO – Deaths in Laois – Monday, March 9, 2020 TAGSDeaths in Laois Facebook News WhatsApp Electric Picnic Deaths in Laois – Tuesday, March 10, 2020 Pinterest Bizarre situation as Ben Brennan breaks up Fianna Fáil-Fine Gael arrangement to take Graiguecullen-Portarlington vice-chair role Twitter By LaoisToday Reporter – 10th March 2020 Twitter Home Deaths Deaths in Laois – Tuesday, March 10, 2020 Deaths Pinterestlast_img read more

Three B.C. men illegally traded and distributed securities: BCSC

BCSC sanctions founders, companies in failed insurance venture Between August 2005 and June 2008, Mitschele, Michael Minor and Tim Minor distributed PVT shares to approximately 322 investors, raising around $5.2 million. At the time of the distributions, Mitschele was president and CEO of PVT, a B.C. company whose business was the development and commercialization of parking meter technology. Michael Minor was a director of the company. In a statement of admission dated December 18, 2011, Michael Minor and Tim Minor admitted that they “traded and distributed $3.2 million worth of PVT securities without being registered or having filed a prospectus, and when no exemptions from the registration and prospectus requirements applied”, and in doing so contravened B.C.’s securities laws. The panel found that PVT traded $3.5 million in PVT shares to 272 investors without being registered or having filed a prospectus with no applicable exemptions, and in doing so contravened securities laws. The panel also found that Mitschele, as president and CEO of PVT, breached securities laws when he authorized, permitted and acquiesced in PVT’s contraventions of securities laws. The panel directed the parties to make submissions on sanctions according to the schedule set out in the findings. Keywords Illegal distributionsCompanies British Columbia Securities Commission Related news A British Columbia Securities Commission panel has found that three B.C. men and a parking technology company illegally distributed securities when they raised approximately $3.5 million from investors who did not qualify for exemptions from securities laws. The panel found that Photo Violation Technologies Corp. (PVT), Frederick Lawrence Marlatt (a.k.a. Frederick Lawrence Mitschele), Michael Wallace Minor, and Michael Garfield Timothy (Tim) Minor traded in securities without being registered in B.C., and distributed those securities without filing a prospectus. All three men are B.C. residents. Compensation funds available for Phoenix group victims IE Staff Former Alberta planner fined, banned for illegal distribution scheme Share this article and your comments with peers on social media Facebook LinkedIn Twitter read more

European regulators consult on big data

first_img The Joint Committee of the European Supervisory Authorities on Monday launched a public consultation about the potential benefits and risks of big data for consumers and financial firms to determine whether any further regulatory or supervisory actions may be needed. “Big data can generate ideas, solutions or predict certain events or behaviours and is already used in the financial industry,” the Joint Committee says in a statement. FCA to examine the evolving market for trading data Related news Keywords Big data As tech’s role in compliance grows, so do concerns: FSB “The purpose of the consultation is for the ESAs to understand better what the big data phenomenon means for consumers, the financial industry and regulators,” the Joint Committee adds. Existing legislation on data protection, competition and consumer protection, are all relevant to financial firms in this area, but do not explicitly address their use of big data, notes the discussion paper released in conjunction with the consultation. Regulators are now contemplating whether the existing legislative and regulatory framework is sufficiently flexible to cover big data, or whether there are gaps that need to be filled. “The use of big data is likely to transform the way products and services are provided with benefits for consumers (in terms of products/services better tailored to consumers’ needs, better quality or cost-effective services/products) and financial institutions (for instance in terms of more efficient processes and decision-making or better management of risks or fraud situations),” the discussion paper says. “At the same time, the use of big data could potentially also have an impact on consumers’ access to products/services, raise issues around the processing of data and financial institutions’ pricing practices or decision-making using big data technologies, the potential limitations or errors in the data and analytic tools, or security and privacy/ethical concerns, eventually leading to legal and reputational risks for financial institutions,” the paper adds. “Potential entry barriers in accessing big data technologies could also have negative implications on innovation and competition in the financial markets at the detriment of consumers’ welfare,” the discussion paper says. The consultation closes on March 17, 2017. center_img James Langton Pandemic intensifies policymakers’ data needs Share this article and your comments with peers on social media Facebook LinkedIn Twitterlast_img read more

Assets invested in ETFs, ETPs hit new record

first_img Keywords ETF,  Investment funds Canadian ETF inflows top $30B year-to-date How have low-vol ETFs fared during the pandemic? Digital illustration of Financial economic growth concept hywards/123RF Net inflows for the year so far have reached US$373.16 billion, which is “significantly higher” than the pace of inflows a year ago, the release said.Fixed income products recorded the largest inflow in July, at US$34.77 billion, followed by equity products (US$24.28 billion) and commodity products (US$10.32 billion).Flows into fixed income ETFs have so far been higher than any other product category this year, at $140.63 billion, compared with $131.67 billion a year ago.To date, flows into equity ETFs (US$112.92 billion) are slightly lower than they were a year ago (US$114.32 billion), while commodity product inflows (US$64.17 billion) are “much greater” than a year ago (US$7.76 billion).ETFGI reported that the top 20 ETFs by new assets “collectively gathered US$30.32 billion at the end of July.” The majority were focused on the bond market.The top 10 ETPs in July were mainly focused on gold and short-term futures, according to the release. IE Staff Most firms now use model portfolios: survey Related news Facebook LinkedIn Twitter Share this article and your comments with peers on social media Assets invested in ETFs and ETPs globally continued to rise in July thanks to improving markets, according to data from London-based research firm ETFGI.Total invested assets reached a new record of US$6.66 trillion, up 6% from a month earlier. Net inflows for July were US$79.35 billion — “the third highest monthly net inflow on record,” ETFGI said in a release. last_img read more

Prestigious MERIT Award To Aid Prof Seeking Clues To Addiction

first_imgUniversity of Colorado at Boulder Professor Allan Collins has received a prestigious MERIT Award from the National Institutes of Health to continue his research analyzing genetic links between alcohol and nicotine addiction. One of only three MERIT Award winners in the nation selected by NIH this year, Collins will receive roughly $1 million over four years. The funding will help his research team at CU’s Institute for Behavioral Genetics pursue intriguing new lines of research they have uncovered that may lead to improved methods for drug and alcohol abuse prediction and treatment. “I’m delighted and relieved,” said Collins. “The hardest part of my job is coming up with the money each year to pay for the research done by the young people in my lab. Being a faculty member is a bit like being a parent in that we feel a sense of responsibility toward our students and researchers.” Collins, who has been on the CU faculty for 27 years, said no single landmark finding or magic bullet will mitigate the devastating biochemistry of alcohol addiction. “But I’m much more optimistic about the possibilities for diagnosis and treatment than I was 15 years ago,” he said. Although Collins began his career using genetics as a tool to track the biochemical workings of alcohol, he switched to probing the biochemistry and genetics of nicotine addiction after several years, suspecting a link between the two. “It is no coincidence that 90 percent of alcoholics are smokers,” he said. In 1983, Collins’ group was the first in the world to show that chronic nicotine use in lab mice increased the number of nicotine receptors in their brains. Nearly a decade later, his group discovered that some of the receptors in the brains of mice became deactivated and desensitized to nicotine over time. “I call findings like these bricks in the wall of knowledge” said Collins. “Taken together with other findings, they can help us build a model of what type of genetic and biochemical processes in the human brain influence addiction.” Recent experiments in Collins’ lab indicate there is some overlap in genes that regulate sensitivity to alcohol and genes controlling sensitivity to nicotine. In a nutshell, mice subjected to chronic nicotine treatment show a reduced sensitivity to alcohol. “This suggests both alcohol and nicotine have common mechanisms in the nervous system,” Collins said. In one series of tests, three strains of mice that exhibited markedly different responses to alcohol were offered alcohol mixed with nicotine. Interestingly, the mice that preferred “moderate” amounts of alcohol increased their consumption of nicotine-laced alcohol considerably, while the “teetotaling” and alcoholic strains of mice showed no discernable difference in preference. Since mice and humans have similar genes linked with biochemical responses to alcohol and nicotine, such studies may indicate that adolescents who begin smoking at an early age may be at a higher risk for alcoholism. “By the time these kids take their first drink, they may well be less sensitive to alcohol,” he said. “And people who are less sensitive to alcohol have a significantly greater chance of becoming alcoholic.” Recent work in Collins’ lab led by Research Associate Ying Lu showed that nicotine releases an inhibitory brain neurotransmitter known as GABA that dulls neuronal circuits related to anxiety, said Collins. Scientists already knew alcohol enhanced the release of GABA neurotransmitters. But surprisingly, the CU-Boulder team showed the chronic use of nicotine in mice decreased the release of GABA, as did the chronic use of alcohol. “This shows us that two different drugs working at different places both have the same effect on the system,” he said. Collins said the experiments are interesting leads to a complex problem. “They may offer us another target, a system in the brain that could be manipulated to alter the course of alcoholism or enhance alcohol therapy.” The MERIT award will allow Collins and his team to undertake follow-up studies on the findings, he said. “It’s risky research, and it might take two or three years to chase down the answers. But the MERIT Award will allow us to follow what we think are promising leads that could result in new breakthroughs.” Published: April 29, 1998 Share Share via TwitterShare via FacebookShare via LinkedInShare via E-maillast_img read more