Anadarko Petroleum Corporation has entered into an agreement with the plaintiffs (the “Litigation Trust”) in the Tronox Adversary Proceeding to resolve all claims against Kerr-McGee Corporation and certain of its subsidiaries and affiliates (collectively “Kerr-McGee“), which stemmed from alleged actions by Kerr-McGee prior to its acquisition by Anadarko in 2006. Kerr-McGee is now a wholly owned subsidiary of Anadarko.“This settlement agreement with the Litigation Trust and the U.S. Government eliminates the uncertainty this dispute has created, and the proceeds will fund the remediation and cleanup of the legacy environmental liabilities and tort claims,” said Anadarko Chairman, President and CEO Al Walker. “Investor focus can now return to the tremendous value embedded in Anadarko’s asset base, allowing our peer-leading operational and exploration results to again become the basis for valuation. We are grateful to our stakeholders who have maintained their confidence and trust in our people and our assets.”In exchange for a complete release of all claims asserted against Kerr-McGee, Anadarko has agreed to pay a total of $5.15 billion to the plaintiffs, which represents a principal sum of approximately $3.98 billion and 6-percent interest thereon from the filing of the complaint in May 2009. Under the terms of the settlement agreement, the Litigation Trust and Kerr-McGee have agreed to mutually release claims against each other, and the U.S. Government and Kerr-McGee have provided mutual covenants not to sue. The U.S. Government also will provide contribution protection from third-party claims seeking reimbursement from Kerr-McGee at more than 4,000 sites covered by the covenants.The settlement agreement is subject to recommendation by the U.S. Bankruptcy Court and approval of the U.S. District Court, both in the Southern District of New York, and the issuance of an injunction barring similar claims from being asserted by third parties.“As we highlighted during our recent investor conference, Anadarko’s employees have continued to deliver remarkable results that have not been fully recognized by the equity markets due to the potential implications of this case. Together with our efficient allocation of capital and active portfolio management, the company’s industry-leading exploration success and strong, transparent, and sustainable growth metrics uniquely position Anadarko amongst its peers. We look forward to having our exceptional results become the foundation for even greater operating and share-price performance through the balance of this decade and beyond,” added Walker.The Company expects the Tronox Adversary Proceeding to be stayed pending final approval of the settlement agreement. The settlement payment is to be made after the District Court’s approval of the settlement agreement and issuance of the injunction are final and non-appealable. The claims asserted in the Tronox Adversary Proceeding will be dismissed with prejudice after the settlement payment is made. This process is currently expected to be completed prior to the end of the third quarter of 2014. The Company’s significant cash position and available $5 billion credit facility provide flexibility in funding the settlement payment.The Company expects the impact of the settlement agreement to be reflected in its first-quarter 2014 financial statements. The Company estimates it will record a gross tax benefit of approximately $1.65 billion associated with the settlement, offset by approximately $1.10 billion in uncertain tax positions, currently resulting in a net tax benefit of approximately $550 million. [mappress]Press Release, April 03, 2014
Boeing says 737 Max software upgrade is complete FILE PHOTO: A worker walks past unpainted Boeing 737 MAX aircraft seen parked in an aerial photo at Renton Municipal Airport near the Boeing Renton facility in Renton, Washington, U.S. July 1, 2019. Picture taken July 1, 2019. REUTERS Revelations have emerged in released instant messages from 2016, where a top Boeing Co 737 MAX test pilot tells a colleague that “The jet’s MCAS flight control system – the same one linked to two fatal crashes – was running rampant in the (simulator) on me.”FILE PHOTO: Employees walk by the end of a 737 Max aircraft at the Boeing factory in Renton, Washington, U.S.-REUTERSBut the broader conversation appears to show the Boeing pilot was also grappling with a number of software problems with the flight simulator itself, according to a former Boeing test pilot who analyzed the transcript and who had direct knowledge of the flight simulator at the time.Such calibration problems may have contributed in some way to then-chief technical pilot Mark Forkner’s observations and conclusions about MCAS’ behavior, the former pilot, and a second former Boeing engineering employee, Rick Ludtke, said.The messages, first reported by Reuters, appear to be the first publicly known observations that MCAS behaved erratically during testing before the aircraft entered service.They sent Boeing’s shares tumbling, prompted a demand by U.S. regulators for an immediate explanation, and a new call in Congress for the world’s largest plane maker to shake up its management.At one point during the 9-minute conversation, Forkner tells colleague Patrik Gustavsson that he was in his hotel room “with an ice cold grey goose” after a session on a flight simulator earlier in the day.The Nov. 16, 2016 conversation took place four months before the U.S. Federal Aviation Administration certified the MAX, the latest iteration of Boeing’s 737 aircraft, and two years before deadly crashes in Indonesia and Ethiopia killed 346 people.That simulator, likely supplied by Textron Inc company TRU Simulation + Training, was also still months away from winning FAA certification and had numerous technical problems that affected its performance, the former Boeing pilot said.“But there are still some real fundamental issues that they claim they’re aware of,” Forkner said, likely referring to the manufacturer.Boeing declined to comment.Forkner’s lawyer David Gerger told Reuters: “The simulator was not reading right and had to be fixed to fly like the real plane.”Boeing has said MCAS only operates when the flaps are retracted, so it would be unusual that Gustavsson would have experienced the same behavior on approach, with flaps extended, the former Boeing employees said.Pilots have complained they did not know about the existence of MCAS before the Lion Air crash in October 2018. In a separate set of emails released by the FAA on Friday, Forkner told the agency in January 2017 that the company would delete references to MCAS from the flight operator’s manual “because it is outside the normal operating envelope.”Related Boeing defends 737 Max as countries suspend use of aircraft Boeing admits flaws in 737 MAX simulator software
Click here or on the image above to view it at full size in a new window. Dave NatzkeEditorProgressive DairymanEmail Dave Natzkedave@progressivepublish.com The 116th Congress features 100 new members of the House: Democrats now have a 235-197 majority, with three vacancies as of February 2019. In the Senate, Republicans expanded their majority to 53-47.advertisementadvertisementProgressive Dairyman provides the names of House and Senate committees and subcommittees and their members with oversight on issues directly impacting dairy in the 116th Congress.1. AgricultureSenate: U.S. Sen. Pat Roberts (R-Kansas), will again chair the U.S. Senate Committee on Agriculture, Nutrition and Forestry. Roberts, 82, has worked on eight farm bills. He’s the only lawmaker to chair both the House and Senate Ag Committees. Roberts won’t seek re-election in 2020. Sen. Debbie Stabenow (D-Michigan) remains the top Democrat on the committee and continues serving as the ranking member.There are 11 Republicans on his committee, but the Democratic roster shrunk by one seat and is down to nine. Both the Republicans and the Democrats have added one new senator to the Agriculture Committee’s ranks: Sen. Mike Braun (R-Indiana) and Sen. Richard Durbin (D-Illinois).Much of the work in 2019 will focus on working with the USDA to implement the 2018 Farm Bill, including the Dairy Margin Coverage Program (DMC). The Senate Agriculture Committee is expected to play a key role in the upcoming reauthorization of the Child Nutrition Act.House: With the new Democratic majority, Rep. Collin Peterson (D-Minnesota) is chair of the House Agriculture Committee, replacing Rep. Mike Conaway (R-Texas), who will now serve as the ranking member.advertisementThere are 26 Democrats on the committee, including about a dozen newcomers; there are only three new Republican members.California has the most representation on the committee with six members; five states have three members on the committee: Florida, Georgia, Illinois, Minnesota and New York. Rep. Jim Costa (D-California) chairs the subcommittee on livestock and foreign agriculture.2. AppropriationsSenate: Sen. Richard Shelby (R-Alabama) is chair of the Senate Committee on Appropriations. Ranking member and vice-chair is Sen. Patrick Leahy (D-Vermont).The Senate Appropriations Agriculture, Rural Development, Food and Drug Administration, and Related Agencies Subcommittee has oversight on the USDA (except Forest Service), the Farm Credit Administration, Commodity Futures Trading Commission and Food and Drug Administration. There are seven Republicans and six Democrats on that subcommittee. Sen. John Hoeven (R-North Dakota) is chair; Sen. Jeff Merkley (D-Oregon) is ranking member.House: The House Committee on Appropriations is led by Rep. Nita Lowey (D-New York), chair; ranking member is Rep. Kay Granger (R-Texas).The Agriculture, Rural Development, Food and Drug Administration, and Related Agencies subcommittee oversees most USDA programs. There are seven Democrats and four Republicans on that subcommittee. Leadership is Rep. Sanford Bishop Jr. (D-Georgia), chair; and Rep. Jeff Fortenberry (R-Nebraska), ranking member.advertisement3. JudiciarySenate: Sen. Lindsey Graham (R-South Carolina) is chair of the Senate Judiciary Committee. Ranking member is Sen. Dianne Feinstein (D-California).Probably of most importance to dairy is the Subcommittee on Border Security and Immigration, which oversees immigration, citizenship and refugee laws. There are nine Republicans, led by subcommittee chair Sen. John Cornyn (R-Texas), and eight Democrats, led by ranking member Sen. Dick Durbin (D-Illinois).House: The House Judiciary Committee is led by Rep. Jerrold Nadler (D-New York), chairman; and Rep. Doug Collins (R-Georgia), ranking member.The Subcommittee on Immigration and Citizenship has jurisdiction over immigration and naturalization, border security, admission of refugees, treaties, conventions and international agreements. The nine Democrats on that subcommittee are led by Rep. Zoe Lofgren (D-California), chair; and Rep. Pramila Jayapal (D-Washington), vice-chair. The six Republicans are led by Rep. Ken Buck (R-Colorado), ranking member.4. TradeCommittees with primary oversight on trade include the Senate Finance Committee and the House Ways and Means Committee.Senate: The Senate Finance Committee includes 15 Republicans, led by Sen. Chuck Grassley (R-Iowa), chair; and Sen. Ron Wyden D-Oregon), ranking member.Oversight on trade issues rests with the Subcommittee on International Trade, Customs, and Global Competitiveness. It has 11 Republicans and nine Democrats. Chair of the subcommittee is Sen. John Coryn (R-Texas); ranking member is Sen. Robert Casey (D-Pennsylvania).House: The House Ways and Means Committee includes 25 Democrats, led by Rep. Richard Neal (D-Massachusetts), chair; and 17 Republicans, led by Rep. Kevin Brady (R-Texas), ranking member.The Subcommittee on Trade is responsible for matters related to international trade, including customs, tariffs, the negotiation and implementation of reciprocal trade agreements, and international trade rules and organizations. It has 11 Democrats and seven Republicans. Chair of that subcommittee is Rep. Earl Blumenauer (D-Oregon); ranking member is Rep. Vern Buchanan (R-Florida).5. Congressional Dairy Farmer CaucusSix co-chairs have been named to head the Congressional Dairy Farmer Caucus, a bipartisan group dedicated to educating other members of Congress and building political consensus on the importance of the dairy industry to the nation’s economy. While it’s called the “Congressional Dairy Farmer Caucus,” it is made up of only House members. As of Progressive Dairyman’s deadline, the full list of Congressional Dairy Farmer Caucus members was not available. * Chairs and ranking members of House and Senate committees are ex-officio members of all subcommittees. Even though the 2018 Farm Bill provided dairy safety net program changes for the next five years, Congress will debate issues directly impacting dairy farmers. Immigration, trade and environmental policies are chief among those, and grassroots efforts are already underway to reform other dairy policies. The New Green Deal looms.
PARMA, OHIO – The Normandy Invaders are coming off their first win in nearly five years last week, and tonight will look to go 2-0 as they play host at 7pm to the Lincoln-West Wolverines to start week two of the 2017 season, and you can catch all the action LIVE right here on NEOSI!The matchup at Byers Field will kickoff at 7pm, and you can not only listen to all the action but WATCH the game as it’s played on Youtube Live!Check HERE to watch Matt Loede and Eli Mooneyham LIVE from Byers Field, as both the Invaders and Wolverines do battle in this non-conference matchup. Related TopicsLincoln-West WolverinesNormandy Invaders Matt Loede has been a part of the Cleveland Sports Media for over 21 years, with experience covering Major League Baseball, National Basketball Association, the National Football League and even high school and college events. He has been a part of the Cleveland Indians coverage since the opening of Jacobs/Progressive Field in 1994, and spent two and a half years covering the team for 92.3 The Fan, and covers them daily for Associated Press Radio. You can follow Matt on Twitter HERE. Matt Loede
AD Quality Auto 360p 720p 1080p Top articles1/5READ MORECoach Doc Rivers a “fan” from way back of Jazz’s Jordan ClarksonCompensation for work distributed via the Internet and other digital media has been central to the contract dispute. The guild also has called for unionization of writers working on reality shows and animation. The union responded by saying the contract proposals by the big studios would cause writers even more economic harm in the future. “To sidestep this fact, they erroneously claim we are focused on other issues,” the guild said in a statement. “The conglomerates are responsible for creating the economic havoc. They should put their energies into making a fair deal with writers rather than issuing misleading statements.” The strike that began Nov. 5 has also been costly for other industry workers. Production has been shut down on dozens of TV shows, with losses for crew members exceeding $250 million, according to the alliance message. The alliance Web site features a constantly updated ticker with the studios’ estimate of writers’ losses. The figure is based on West Coast guild data from 2006, the site said. Hollywood studios said Friday that striking writers have now lost more in salary and benefits than they had hoped to gain by walking off the job. In the message posted on its Web site and YouTube, the Alliance of Motion Picture and Television Producers claimed losses by writers in the eight-week strike have exceeded $151 million. That’s the price tag the Writers Guild of America put on its proposed three-year deal with studios. “The strike continues because the union’s leaders are focused on jurisdictional issues that would expand their own power, at the expense of the new media issues that working writers care most about,” the alliance said in a statement. Talks broke down Dec. 7 after the union rejected an alliance demand that a half-dozen guild proposals be taken off the table, including jurisdiction over reality and animation writers. While negotiations with the writers union are at a standstill, studios are preparing to begin contract talks with the Directors Guild of America, perhaps next month. Digital compensation also is expected to be a key issue for directors. Whether a deal by directors will affect the writers dispute is unclear. The guilds traditionally have followed a practice of pattern bargaining, with one contract considered a template for others. But the writers guild has said previously that it wishes the directors well, but noted they “do not represent writers. Our strike will end when the companies return to negotiations and make a fair deal with the WGA.” The directors guild has gone on strike only once, for just five minutes in 1987.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!
4 November 2010 Baloyi added that the municipal sector currently constitutes 50% of the DBSA’s loan book. “Electricity is a major component of municipal revenue, and it is only logical for the Bank to contribute to the funding of projects that will help to ensure a secure supply of energy for South Africa,” he said. After a thorough environmental analysis, the bank’s environmental appraisal report concluded that fossil fuels would remain dominant in South Africa’s energy mix for some time, but technologies to reduce greenhouse gas emissions are being developed globally and Eskom’s projects will use some of these technologies to reduce emissions. “Building a sustainable and secure energy supply is one of many priority areas that the DBSA will aggressively pursue to complement the government development agenda to address key development and socio- economic issues faced by the country,” Baloyi said. State power utility Eskom has secured a R15-billion loan from the Development Bank of Southern Africa (DBSA) to fund its capital expansion programme. The loan, which is a structured facility that will be drawn over five years, does not utilise guarantees from the South African government. Reducing environmental impact The projects include the Medupi and Kusile coal-fired power stations as well as the Ingula Pump Storage scheme and associated transmission infrastructure. Like any other transaction, the Eskom loan was subjected to the DBSA’s environmental appraisal guidelines, which found that Eskom has the institutional capacity to address current and future climate change related risks. Securing future energy supply Eskom’s capacity expansion programme is expected to have large spin-off effects, creating 40 000 new jobs, stimulating the creation of new industries and new suppliers, and adding almost 1% a year to the economic growth rate. It will also have a significant impact on the economies and communities of the towns in which the new power stations are located. SAinfo reporterWould you like to use this article in your publication or on your website? See: Using SAinfo material Eskom’s capacity expansion projects will add 12 300 megawatts of additional generating and transmission capacity to South Africa’s national grid by 2017, enabling it to keep up with growing demand. Supporting growth and development Eskom CEO Brian Dames welcomed the recognition by the DBSA of the critical role that Eskom and its capacity expansion programme have to play in supporting South Africa’s growth and development. “Our new build programme is essential to provide the security of supply that South Africa needs if it is to grow its economy and improve the quality of life for all of its people,” Dames said. “The loan is a vote of confidence by the DBSA in Eskom. “It will help us to provide South Africa with the power stations and transmission infrastructure it needs while ensuring that Eskom remains financially sustainable.” Speaking at the media briefing in Johannesburg this week, DBSA chief executive Paul Baloyi said: “This deal signifies a major step change aimed at ensuring that South Africa’s long term electricity supply meets demand to ensure the economy can thrive.”
A mother was inside a South Carolina Walmart for more than an hour while her two small children were left inside a vehicle, according to arrest warrants. Alyssa Gabriella Oliver is charged with two counts of unlawful conduct toward a child.Arrest warrants released Thursday afternoon reveal that several witnesses saw a seven-month-old and 20-month-old crying and sweating heavily in the backseat of the vehicle on Tuesday. Officers managed to get the two children out of the vehicle. The children were taken to the hospital for treatment.An officer spoke with a loss prevention officer inside the store on South Irby Street, who said Oliver was seen parking her vehicle and walking into the store at 1:41 p.m. without her children, the warrant states. Documents show the officer located Oliver as she was leaving the store at 2:50 p.m.- Sponsor – The arrests warrants say the temperature inside the vehicle was checked by an infrared thermometer and it read 110 degrees. Oliver is currently at the Florence County Detention Center under a $50,000 bond. The children were placed in the care of South Carolina Department of Social Services… WMBF News Stay UpdatedGet critical information for loss prevention professionals, security and retail management delivered right to your inbox. Sign up now
mike kirkwood A Web Developer’s New Best Friend is the AI Wai… Tags:#cloud#saas And, the authorization to ‘Buy Now’. 8 Best WordPress Hosting Solutions on the Market This feature is available to any Apple affiliate, but we find it particularly effective coming from the artist embedded with the video and other endorsements.Tweeting, End to End, Facebook, FTWWe noticed that with a simple interaction, we can logon to Facebook and Twitter from LadyGaga.com and drop a status post, or “tweet” into Facebook or Twitter. Incredibly, inside iTunes, both services are available as well. The real story is that social networks, and commerce networks work together, end-to-end, and, for-the-win. In a twist of fate, in this version of digital music future the record labels win big. They do it by being close to both eyeballs (Google) and library (Apple), and bringing out the thing they know, the pop. LadyGaga is on a rollWith the help of Twitter, Facebook, Google, and Apple she will connect to more platforms than ever before, with fewer clicks and passwords. We wonder how this evolve further into other platforms. Will LadyGaga’s services continue to find new ways to leverage real-time services? We’re starting to envision personal mobile and location aware fan applications. Will the forces of cloud computing and commerce force Apple and Google be best-friends-forever in music? And, will we ever build a phone that doesn’t disrupt us while on the dance floor?And, for god’s sake, damn, Beyonce’ has her back.Top photo credit: Lady Gaga at CES 2010 Lady Gaga, along with her record company, is evolving the album in the form of software as a service. Considering the content of her hit new video, Telephone, it is fitting that she would use software to tackle the hard problem of getting paid by amazing fans.On her path to global dominance, the site, LadyGaga.com has innovated the next generation of brand management for artists. To do this, she creates a join between Google’s YouTube, Apple’s iTunes, Twitter, and Facebook. Way beyond having a an Twitter account, LadyGaga is hosting an interface party, and you’re invited. She’s a performer who is inventing ways to create the value of using multiple platforms to juice the network effects.Commerce 2.0Like it a lot? Take a souvenir home from the party for the low introductory price of $1.99 in your iTunes.Today, we noticed another cultural icon, VC Fred Wilson posted this question on his blog as to what will emerge as Commerce 2.0. iTunes is prominently offered for both buying the video (which is also free on the same page) and also the album. So, there is a bet here that people want to own it, or place value in their iTunes library to offer this connected service. This brings the user to a one-moment to buy scenario. Shown here, there is the familiar transition to iTunes from the LadyGaga site. In default mode, iTunes is set to require a validation step (a second click) to buy the media. The user can can be set easily to bypass this step and enable the user one-click to buy from the web in the future. Related Posts Top Reasons to Go With Managed WordPress Hosting Why Tech Companies Need Simpler Terms of Servic… “So the question is who will the YouTube, Facebook, and Twitter of commerce be? Maybe they exist today and will emerge as large scale web services soon. Or maybe they are still ideas in the minds of entrepreneurs and will be hatched in the coming years.It’s an area I am excited about and will be on the lookout for. Clearly I’m not the only one.”This is where we think LadyGaga.com’s promotion for Telephone stands out as an example of the new world economy. This world is connected by the best ad engines of Google. And it is directly connected to Apple’s amazing commerce engine. Apple, in the context of digital goods is showing how extremely well it is positioned to be the industry payment engine. Embedding YouTube: Get it Now, AnywhereWe witnessed YouTube transition from the Wild West to a control point for record labels. Now, a lot of the newest official artist videos flow straight to Vevo, the branded label friendly site that runs ads and controls the experience of the brand. YouTube is taking advantage of its place as a channeling service for video. In this case, the top, most requested inventory pays for the rest of the service. The higher the demand, the more attention it gets. LadyGaga.com, like many sites, uses embeddable YouTube. In addition to pointing to commerce services like iTunes, the video embeds curated links into other properties at Vevo. This provides the site custom promotion experience while leveraging the YouTube and Vevo distribution channel.
Chemists looking to design and test new medicines are awash in a sea of bad data, according to a report released today by an international panel of experts. The panel, made up of researchers from 46 nonprofit institutions, universities, and biotech and pharmaceutical firms, say they are setting up a TripAdvisor-like crowdsourcing portal to disseminate up-to-date information about chemical probes that they see as the heart of the problem.The issue with faulty chemical probes has been growing rapidly in recent years. These small, druglike molecules are used primarily to block the activity of specific proteins to determine their roles in biochemistry. Ideally, this helps researchers design drug compounds that perform similar functions but retain attributes needed for successful medicines, like nontoxicity and the ability to travel through the human body. Today, thousands of such probes exist. But most of them interact with nontarget proteins as well or have other unwanted “off-target” effects.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)“It’s become a really serious problem,” says Paul Workman, a chemical biologist and chief executive of the Institute of Cancer Research (ICR) in London, who was a member of the expert panel. The upshot, say Workman and others, is that many probes produce spurious results that can lead researchers to wrong conclusions about the proteins and drug molecules they are studying. For example, some probes have been found to cause side effects, such as triggering chemical changes in proteins or causing proteins to clump together in aggregates that damage cells. And that, the panel argues today in a commentary in Nature Chemical Biology, leads to uncounted hours of wasted time, effort, and money on the part of biomedical researchers. Several years ago, for example, poor chemical probe data led researchers to pursue a final stage clinical trial on a cancer drug candidate called iniparib. Such trials typically cost hundreds of millions of dollars. In 2011 iniparib was deemed a failure after it was found to be less effective at hitting its target than initially thought.Despite such failures, researchers often continue to use faulty probes. Up to now, chemical biologists have relied on the normal self-correcting mechanisms of science—journal articles, reviews, and conference proceedings—to set the record straight. But they haven’t worked in this case. “The self-correction has not been effective enough,” Workman says. The issue, he says, is that few researchers have the time or expertise to keep track of exactly which probes are proving successful. Instead, when researchers look for a new probe, most simply go to Google Scholar and gravitate to the probes that have the most citations. But these are often the older, less reliable probes, Workman says. One such probe, known as LY294002, has had 30,000 citations since 1994 and 1100 since the start of 2014. However, Workman says, “It’s a terrible compound, 10 years out of date, with lots of off-target effects.” More accurate probes have been on the market for years, but researchers still use LY294002 because it appears to have a strong track record.Chemical biologists say they hope crowdsourcing will solve the problem. They have set up a new wiki site, called the Chemical Probes Portal, with backing from ICR, the Broad Institute, the Structural Genomics Consortium, and the Wellcome Trust. At the site researchers will be able to add annotations to different chemical probes, to ensure their colleagues have the most up-to-date comparative information they need. The effort could be a challenging one, because even studies that use the same probe often use it in different conditions and at different doses, says Kevan Shokat, a chemical biologist at the University of California, San Francisco. However, he adds, as long as researchers use the portal in an iterative way to steadily improve the understanding of different probes, it should help the community. “I do think that would be a good service,” Shokat says.
Every year sports clubs waste time and money on printing and mailing, but all that can change by becoming a Paperless Club and using your website and emails to inform your members. Make the change and Go Green today – become a Paperless Club.To find out more, visit http://www.sportingpulse.com/mysport.cgi?domain=paperless