A mobile home and a camper had serious damage in a fire just east of Hallsville.Boone County crews had to use brush trucks to get to the fire on East Owens School Road at about 1 p.m. Sunday.No word yet on injuries, or what caused the fire.
Chemists looking to design and test new medicines are awash in a sea of bad data, according to a report released today by an international panel of experts. The panel, made up of researchers from 46 nonprofit institutions, universities, and biotech and pharmaceutical firms, say they are setting up a TripAdvisor-like crowdsourcing portal to disseminate up-to-date information about chemical probes that they see as the heart of the problem.The issue with faulty chemical probes has been growing rapidly in recent years. These small, druglike molecules are used primarily to block the activity of specific proteins to determine their roles in biochemistry. Ideally, this helps researchers design drug compounds that perform similar functions but retain attributes needed for successful medicines, like nontoxicity and the ability to travel through the human body. Today, thousands of such probes exist. But most of them interact with nontarget proteins as well or have other unwanted “off-target” effects.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)“It’s become a really serious problem,” says Paul Workman, a chemical biologist and chief executive of the Institute of Cancer Research (ICR) in London, who was a member of the expert panel. The upshot, say Workman and others, is that many probes produce spurious results that can lead researchers to wrong conclusions about the proteins and drug molecules they are studying. For example, some probes have been found to cause side effects, such as triggering chemical changes in proteins or causing proteins to clump together in aggregates that damage cells. And that, the panel argues today in a commentary in Nature Chemical Biology, leads to uncounted hours of wasted time, effort, and money on the part of biomedical researchers. Several years ago, for example, poor chemical probe data led researchers to pursue a final stage clinical trial on a cancer drug candidate called iniparib. Such trials typically cost hundreds of millions of dollars. In 2011 iniparib was deemed a failure after it was found to be less effective at hitting its target than initially thought.Despite such failures, researchers often continue to use faulty probes. Up to now, chemical biologists have relied on the normal self-correcting mechanisms of science—journal articles, reviews, and conference proceedings—to set the record straight. But they haven’t worked in this case. “The self-correction has not been effective enough,” Workman says. The issue, he says, is that few researchers have the time or expertise to keep track of exactly which probes are proving successful. Instead, when researchers look for a new probe, most simply go to Google Scholar and gravitate to the probes that have the most citations. But these are often the older, less reliable probes, Workman says. One such probe, known as LY294002, has had 30,000 citations since 1994 and 1100 since the start of 2014. However, Workman says, “It’s a terrible compound, 10 years out of date, with lots of off-target effects.” More accurate probes have been on the market for years, but researchers still use LY294002 because it appears to have a strong track record.Chemical biologists say they hope crowdsourcing will solve the problem. They have set up a new wiki site, called the Chemical Probes Portal, with backing from ICR, the Broad Institute, the Structural Genomics Consortium, and the Wellcome Trust. At the site researchers will be able to add annotations to different chemical probes, to ensure their colleagues have the most up-to-date comparative information they need. The effort could be a challenging one, because even studies that use the same probe often use it in different conditions and at different doses, says Kevan Shokat, a chemical biologist at the University of California, San Francisco. However, he adds, as long as researchers use the portal in an iterative way to steadily improve the understanding of different probes, it should help the community. “I do think that would be a good service,” Shokat says.
For the last 10 days, champion double trap shooter Ronjan Sondhi has been in a quandary. For someone who is used to hitting the bull’s eye, he doesn’t know how to react to the taunting SMSes of his first coach, Australian Russell Mark, who has been messaging him after India’s defeat in the first Test in Melbourne.Sodhi’s other Australian friends have joined in, adding to the bulging inbox of his mobile phone after India lost the second Test as well. But Sodhi, a keen cricket follower and a staunch Sachin Tendulkar fan, has gone silent.”My Australian friends, including Russell, have been bombarding me with messages after the defeats. But I’ve not replied for the last 10 days as I don’t know what to say,” Sodhi told MAIL TODAY. “They are teasing me because in shooting, we beat Australia all the time. And when India beats Australia in cricket, I also send similar SMSes to them.”Sodhi, the reigning World Cup Finals winner, copped some more embarrassment for Virat Kohli’s finger gesture in Sydney. “After the Kohli incident, one of my Aussie friends sent a message saying ‘the Indians have forgotten to play with the bat and ball, and now they have started playing with fingers’,” he disclosed. “It was embarrassing.”Not just Sodhi, but the entire Indian sports fraternity seems to be in a state of shock.Sodhi’s senior Mansher Singh, a member of the Indian trap team, and an avid cricket fan, has stronger views. “Every morning I wake up charged, hoping to see India’s revival. But it’s not happening,” he said.advertisement”It’s basically the mindset. The cricketers’ mindset has gone completely haywire. These people have lost out the sharpness to win while the Australians are scoring triple centuries. I’m shocked to see that they can’t stay at the crease and the team loses several wickets in every session. They are in IPL mode, in terms of their thought process,” he pointed out. “They also look fatigued after the World Cup triumph.”Former India hockey captain Zafar Iqbal opined that Dhoni’s men are not playing as a team and lack planning. “The Aussies have the home advantage and, no doubt, they’re a good team. Their teamwork is always very strong, even in hockey. They have a clear-cut game plan and they are not bothered by big names, like a Tendulkar or a Dhanraj Pillay, in the opposition ranks,” he averred.Zafar felt that the famed Indian batting line-up has failed to adjust to the pitches. “What I’ve noticed is that they are not able to play on the bouncier and faster pitches. Also, they (Aussies) have looked more determined than us.”Ace golfer Gaurav Ghei concurred with Zafar. “Obviously, there’s something wrong, if you are not winning. Every time we play, our batsmen have a problem in handling pacers on bouncy pitches. We should get stronger in that area,” Ghei, the first Indian to win an Asian Tour event in 1995, told MAIL TODAY.However, Ghei, known as a gentleman on the circuit, said the criticism should be balanced as cricket should not be treated as just another sport. “It’s more than a game, bordering on fanaticism, considering its large following. It has a different bond with people. We’re very negative about cricketers,” he said.Multiple world billiards champion Michael Ferreira is disappointed too, but agreed with Ghei on the issue of heavy criticism. “We are always ready to criticise; we’ve to remember they too are human beings,” he told MAIL TODAY.Former India football captain Chuni Goswami, who also captained Bengal in the Ranji Trophy, refused to believe that an overdose of cricket could be cited as a reason for the team’s abysmal performance.”Unfortunately, this (defeats) has happened earlier – on the recent England tour. The team has been at sea, but I don’t subscribe to the view that they are playing too much cricket,” said the man who played 46 first-class cricket matches.”Our batsmen can’t play when the ball comes consistently at a height. For eight-nine months, they play on Indian pitches where the ball comes at only knee height and can be tackled by going forward,” said the batsman whose favourite shot was the square cut.Ferreira had the last word: “Forget about the past and get on with the job at hand. Also, my suggestion to my countrymen is: lay off and let them do their job and they’ll come back strongly.”
KOLKATA: The final tally read – Jagmohan Dalmiya: 61, Prasun Mukherjee + Buddhadeb Bhattacharya + Sourav Ganguly: 56. A day after the Cricket Association of Bengal (CAB) election, a fuming Bhattacharya, synonymous with power in West Bengal, proclaimed that this was a “triumph of evil over good”. But none could,KOLKATA: The final tally read – Jagmohan Dalmiya: 61, Prasun Mukherjee + Buddhadeb Bhattacharya + Sourav Ganguly: 56.A day after the Cricket Association of Bengal (CAB) election, a fuming Bhattacharya, synonymous with power in West Bengal, proclaimed that this was a “triumph of evil over good”. But none could defeat CAB’s president, re-elected on July 30 after a nail-biting election.That is because not everyone was against him. At the Maidan, the city’s hub of cricket clubs, his supporters want Dalmiya to continue the “good work”. Dalmiya’s fight for his last piece of turf, after he lost the elections of Board of Control for Cricket in India last year, had indeed turned murky.TRIUMPHANT: Jagmohan Dalmiya (left) after winning CAB pollsIt took a political hue when the chief minister decided it was his duty to get CAB a new president and fielded Police Commissioner Prasun Mukherjee, while advising Dalmiya to steer clear of the elections. Sourav Ganguly, desperate for a recall to the Indian cricket team, changed loyalties to e-mail the Mukherjee camp alleging the current CAB administrators of ruining cricketers’ careers.But Dalmiya won, and humbly said this was just a platform to fight the BCCI cases pending against him. Bhattacharya, who has never tasted political loss, was taken aback by Mukherjee’s defeat. He now has a lot to answer for-CPM stalwart Jyoti Basu and his own partymen want to know why he interfered with the independent election process of a sports body.Basu has also strongly disapproved of Bhattacharya’s public outburst where he demanded, “I want Dalmiya to leave.”The truth remains. Jagmohan Dalmiya is still the king of Bengal cricket, and that is unlikely to change anytime soon. Meanwhile, the inswings continue.advertisement
Jordan delivers on promise: 2 Cobra choppers now in PH The win also allowed Zark’s to surpass its paltry showing in the 2017 Foundation Cup, where it finished 1-9.The Jawbreakers ran to a 15-6 opening salvo and kept their foot on the pedal en route to a 27-point advantage, 109-82, late in the game.Genmar Bragais held the fort for the winless Titans (0-2) with a game-high 29 points and nine rebounds, while Michael Cañete got 22 markers and seven boards.The Scores:ZARK’S BURGER-LYCEUM 109 — Nzeusseu 17, Perez 15, Baltazar 13, Ayaay 12, Jc. Marcelino 12, Tansingco 12, Jv. Marcelino 11, Serrano 5, Cinco 4, Ibañez 4, Marata 4, Liwag 0, Santos 0.AMA ONLINE EDUCATION 85 — Bragais 29, Cañete 22, Manalang 10, Escalambre 8, Casiño 5, Porter 5, Paras 4, Parcero 2, Antonares 0, Garcia 0, Raflores 0, Salonga 0.ADVERTISEMENT SEA Games: PH still winless in netball after loss to Thais ‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claims Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Marcial brings experience, demeanor to PBA Commissioner’s Office LATEST STORIES Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Quarters: 31-19, 61-39, 81-64, 109-85.Sports Related Videospowered by AdSparcRead Next PBA IMAGESShowing no signs of slowing down, Zark’s Burger-Lyceum waylaid AMA Online Education, 109-85, Thursday in the 2018 PBA D-League Aspirants’ Cup at Ynares Sports Arena in Pasig.Cameroonian big man Mike Nzeusseu led the balanced attack for the Jawbreakers with 17 points, including a rim-rattling dunk over Andre Paras with 2:44 remaining to punctuate the victory, along with 10 rebounds, and two blocks.ADVERTISEMENT MOST READ CJ Perez was also one of the seven players who notched double figures in scoring with 15 markers, 14 boards, and five dimes.Wilson Baltazar pumped three treys to wound up with 13 points, Jaycee Marcelino, MJ Ayaay, and Ralph Tansingco all logged 12 points, and Jayvee Marcelino got 11 in the comfortable victory for Zark’s Burger-Lyceum.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingSPORTSPrivate companies step in to help SEA Games hostingAfter gaining back-to-back wins after losing their conference-opener, Jawbreakers coach Topex Robinson praised his wards for sustaining their frenetic pace.“Again, we want to keep on sustaining the energy. We want to change the way the D-League will be played,” he said. “They have to keep up to us rather than us keeping up with the rest of the D-League.” ‘We cannot afford to fail’ as SEA Games host – Duterte PH military to look into China’s possible security threat to power grid BeautyMNL open its first mall pop-up packed with freebies, discounts, and other exclusives Hotel says PH coach apologized for ‘kikiam for breakfast’ claim Don’t miss out on the latest news and information. View comments
TFA are delighted to announce a partnership with Stage and Screen Travel that all the touch community can share and benefit from.Stage and Screen, as preferred supplier to TFA, are able to offer excellent deals for all your travel needs – flights, cars, accommodation, coaches, meeting arrangements and much more.Stage and Screen have a travel consultant dedicated to serve the needs of the touch football community. Touch people are assured of the best possible service at the best possible price.Take the hassle out of your team travel – let Stage and Screen do the run around for you and save money at the same time.Personal travel needs are also catered for and do not need to be touch related.The One Touch Travel Hotline is now up and running. To access, simply click on the new One-Touch icon on left of screen.
Not many opportunities arise in sport where families can represent Australia at the same time, but the creation of the 2013 Super Trans Tasman Series will see several families in the Australian contingent get to share the honour together. One of the families sharing the experience are the Gillards, with Brett representing Australia in the Men’s 50’s side and son Josh wearing the green and gold for the first time from Tuesday in the 20’s Boys team. The Gillards are just one of many family combinations that are in the Australian contingent for the Super Trans Tasman, which include twins Amy and Holly Smith, marriages including Dylan and Emily Hennessey and Erin and Dean Taylor and sisters Sarah and Laura Peattie, just to name a few. We caught up with the Gillards in the lead up to the 2013 Super Trans Tasman Series about sharing the experience together and how much it means to wear the green and gold jersey. Congratulations to both of you for making your respective Australian teams, how much are you looking forward to the Super Trans Tasman Series?Brett: Enormously, it’s always a great opportunity when you play for Australia and it’s extra special to have Josh there, I’m filled with a lot of pride to watch him play, that’ll be really special. Josh: I’m stoked, it’s a pretty big honour to represent your country and like Dad said it’s pretty special that I get to be over there with him. Was it ever a thought that maybe one day you could represent Australia at the same time?Brett: I had always hoped that we may end up somewhere like that, only a couple of years ago we were both playing in the same Premier League side, so that was nice to reach that level. I sort of figured that it wasn’t going to happen at a New South Wales level, we both played State of Origin this year and to back it up with this is really good and quite exciting.What have you told Josh about playing at an Australian level?Brett: Not that much, he only needs to focus on his own game and he knows that, he certainly knows enough to perform at that level. He’s had so many years under his belt of Premier League now, he’ll find it, not easy, but he’ll cope with it quite well. It won’t be the daunting prospect of such a large leap for him. Other than that, he’s only got to focus on his own game and getting that right and I think he’s pretty much there. Josh, what can you tell us about the 20’s Boys team?Josh: We’ve got a really good attacking side, we’ve just got to make sure our defence is good, we’re going to score plenty of touchdowns. It looks like the team has a lot of fun together and gets along very well?Josh: It’s good fun, the coaches are legends, they are good fun to be around. There’s plenty of banter. Brett: They’ve got an enormous boost having Sam Brisby back in the team. That gives them a lot of experience. He played a World Cup in 2011, so he’ll bring a lot to the team. Brett, can you please tell us a bit about your Men’s 50’s side?Brett: We’ve got a plethora of experience, players with enormous ability, three Hall of Famers, Tim Kitchingham, Dave Cheung and Garry Lawless. We’ve got Mick McCall as our assistant coach and Bruce Ager (as coach), he’s quite experienced at this level now. We’ve got a lot of blokes with a lot of experience, there’s only three debutants and the three of them are very strong players. We should do very well. How good is it that you can continue to still play at this level and have similar teams each time?Brett: It’s very good, it’s great to still be able to play around with mates at this level. It shows the benefit of Touch, where Josh and I are still able to play the game and at this level, it is the family game. It is underappreciated for that. How nice is it that you can actually be there to cheer each other on in New Zealand?Brett: It makes it very special, I hope that Josh relishes the moment and enjoys every bit of it but knows he’s got that level of support there with him. It really makes it special, and the reverse for me, it’s nice to know that he’s sitting in the stands watching. Josh, how much has your Dad helped you over the years?Josh: An unbelievable amount, he’s put in plenty hours on and off the Touch field, he would have spent at least three years with me and all of our younger friends developing us, making us better players. And just the one-on-one stuff with me, we spend two or three days a week at least over at the park practicing individual skills.And it must be nice to see a lot of the younger Manly players coming through and representing Australia in those age groups?Brett: That started with Josh’s age group, with Sam Brisby and Simon Lang, that was the group that started the development, Daniel Chiddy was a part of that too. To recognise there was a need there and that’s when we got serious about it and really started to develop those guys and we’ve kicked it on since there and that’s been the bonus for Manly, a lot of that development has gone on and developed into Scorpions. There are plenty of ways that you can keep up-to-date with all of the latest news and results from the 2013 Super Trans Tasman Series, which is taking place in Auckland from Tuesday, 5 February until Sunday, 10 February 2013. Touch Football Australia will be reporting live during the games on its social media pages, which can be found by clicking on the links below:Facebook – www.facebook.com/touchfootballaustraliaTwitter – www.twitter.com/touchfootyaus (be sure to use the #transtasman2013 hashtag)Instagram – Search for ‘Touch Football Australia’The www.austouch.com.au and www.transtasman.mytouchfooty.com websites will have all of the latest news, information, stories and match reports uploaded to the sites. Highlights from the series will also be uploaded to the Touch Football Australia YouTube channel throughout the event – www.youtube.com/touchfootballaus. Be sure to also send in your message of support to the Australian teams in the lead up to the series, which will then be posted on the www.austouch.com.au website in the lead up to and during the series. You can do this through any of our social media sites or send an email to firstname.lastname@example.org with your message.Related LinksSTT A Family Affair
Real Madrid, Barcelona target Liverpool boss Klopp AND Van Dijkby Paul Vegasa month agoSend to a friendShare the loveLiverpool boss Jurgen Klopp AND Virgil van Dijk are being linked with a LaLiga move.AS says the German’s success with the Reds has him being discussed inside the boardrooms of Real Madrid and Barcelona.With doubts persisting at Barca over coach Ernesto Valverde and inside Real regarding Zinedine Zidane’s return, it’s been suggested Klopp is emerging as the prime target for both clubs should choose to change.And it’s also claimed, with the LaLiga rivals keen on Van Dijk, their best shot at landing the Dutchman would be hiring Klopp as coach.For his part, Klopp has insisted he’s happy at Anfield and should the time come to part ways he would be taking a break from the game. TagsTransfersAbout the authorPaul VegasShare the loveHave your say
Last week, Ohio State senior quarterback Braxton Miller posted a photo on Instagram that was believed by some to possibly be an NCAA violation. Miller, a rep for Authentik Fitness, promoted the nutritional products in the photo and listed his email as a point of contact for potential buyers. Under NCAA bylaws, student-athletes are not allowed to use their likeness to help companies profit. According to Urban Meyer, though, “everything is fine” and there is “no issue.” Urban Meyer answers @CantonRepdotcom ? About Braxton Miller NCAA endorsement issue “everything is fine. No issue.”— toddporter (@toddporter) March 30, 2015That’s, obviously, good news for Ohio State fans. The Buckeyes open their 2015 season Sept. 7 against Virginia Tech. Will Miller be the man behind center?
TORONTO – European financial technology company TransferWise is planning a Canadian launch next year for its borderless debit card, which allows users to hold balances in multiple currencies and spend it at home and abroad with lower foreign exchange fees than traditional banks.TransferWise CEO and co-founder Kristo Kaarmann says the card, which was launched in the U.K. and the Eurozone two weeks ago, is useful for frequent business travellers, snowbirds and expats who spend lots of time outside of Canada but domestically as well.“When people go out of the country, they are inevitably spending money,” Kaarmann said in an interview. “They’re booking hotels, they’re booking flights, often in other currencies, and that’s where banks scoop the hidden fees.”Kaarmann said there would be no transaction fees for people making purchases on the borderless debit card in the currency a balance is held in. If money held in the borderless account must be converted into another currency before using the card, a conversion fee of between 0.6 per cent and one per cent applies, which Kaarmann notes is less than the banks charge.The U.K.-based fintech launched its borderless account in Canada in August last year, and Kaarmann said it is working to offer the accompanying debit card here in 2019.There is no limit on the balance that can be held in the borderless account, he says. Customers’ money is held in segregated accounts at banks insured by the Canada Deposit Insurance Corp., according to a TransferWise spokeswoman.Kaarmann spoke about its borderless card as it launches its batch payments function in Canada, which allows businesses to make up to 1,000 global payments at once in various currencies with a lower foreign-currency conversion charge of between 0.6 per cent and 1 per cent.TransferWise has been beefing up the functionality offered to Canadians since its launch in April 2016. Since then, roughly $2.2 billion has been moved in and out of the country via TransferWise’s platform. Canada is among its top 10 largest markets and is now the sixth-fastest growing market in terms of transfers.Canada’s big banks are investing heavily in technology as customers increasingly do their banking in the digital realm. They are also facing increased competition from non-traditional providers of payment services. For example, Apple and Google have introduced mobile wallets that allow users to make retail payments.Meanwhile, last month, TransferWise became the first non-bank payment services provider to hold a settlement account in the Bank of England’s Real Time Gross Settlement system, meaning it can now settle payments directly rather than going through a retail bank.As Canada moves to modernize its payment system, TransferWise is pushing for a similar direct settlement account in Canada as well as policies regarding the disclosure of fees, including exchange rates.Note to readers: This is a corrected story. An earlier version of this story reported that TransferWise is working to launch a debit MasterCard in Canada.